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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05663281
Other study ID # 301Titan
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date December 15, 2022
Est. completion date December 31, 2027

Study information

Verified date February 2023
Source Chinese PLA General Hospital
Contact Jinhao Lyu, M.D.
Phone +8615903562929
Email 330322990@qq.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

In the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment.


Description:

Cerebral ischemic stroke resulting from thrombosis causes high disability and mortality. There are few biomarkers to evaluate arterial thrombophilia until now. Previous studies have demonstrated that atherosclerotic plaque rupture and erosion are major etiologies initiating thrombosis. Based on previous works targeting the role of plaque and blood flow in cerebrovascular disease, in the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to explore the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment. The study's objective was to solve the challenges in the mechanism of thrombus features and the outcome of recanalization therapy, thus helping improve the primary and secondary prevention of cerebrovascular disease.


Recruitment information / eligibility

Status Recruiting
Enrollment 100
Est. completion date December 31, 2027
Est. primary completion date December 31, 2027
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Age = 18 years - Extracranial and/or intracranial artery occlusion confirmed by angiography - Available for magnetic resonance high-resolution vessel wall imaging - Written informed consent obtained Exclusion Criteria: - Extracranial and/or intracranial artery mild to moderate stenosis - Pregnant women - Restenosis or occlusion after artery stenting placement

Study Design


Related Conditions & MeSH terms


Intervention

Diagnostic Test:
thrombus imaging appearance
Imaging appearance of intracranial and/or extracranial arterial thrombus

Locations

Country Name City State
China Chinese PLA General Hospital Beijing Beijing

Sponsors (1)

Lead Sponsor Collaborator
Chinese PLA General Hospital

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary Rate of Successful Recanalization Antegrade blood flow through the recanalized portion was assessed by thrombolysis in myocardial infarction (TIMI) score or thrombolysis in cerebral infarction (TICI) score. TIMI=2 or TICI=2b was defined as successful recanalization. 1-3 Years
Primary Ischemic Stroke Occurrence Ischemic stroke occurrence during follow-up period which was confirmed by neuroimaging 1-3 Years
Secondary Number of Participants with Adverse Events hemorrhagic or ischemic stroke after recanalization treatment 1-3 Years
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