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NCT03180567 Clinical Trial

Pharmacogentic Screening of Coumarine Based Oral Anticoagulant Using Next Generation Seguencer

Thrombosis Clinical Trial

Official title:
Pharmacogentic Screening of Coumarine Based Oral Anticoagulant Using Next Generation Seguencer

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03180567
Other study ID # Prof Amr gawaly
Secondary ID
Status Recruiting
Phase N/A
First received June 6, 2017
Last updated June 6, 2017
Start date June 6, 2017
Est. completion date December 2020

Study information
Verified date June 2017
Source Tanta University
Contact Amr Gawaly, Ass Prof
Phone 01221793033
Email amrgawaly1@yahoo.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

As drug response is a complex trait in the majority of cases using an optimal starting dose for an individual may reduce the time taken to reach a stable INR, and reduce the risk of having either a high INR (with a risk of bleeding) or a low INR (with a risk of thrombosis)

Description:

The results of this project will benefit in (1) Identification of novel features or mutation types in warfarin resistance genomes. (2) To determine whether other polymorphisms in noncoding regions or their unique haplotype combinations contribute to the variability in the maintenance dose of warfarin, and (3)personalization of the drug and deciding the correct dose from the start.

Recruitment information / eligibility
Status Recruiting
Enrollment 20
Est. completion date December 2020
Est. primary completion date December 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Patients with thrombosis and warfarin resistance

Exclusion Criteria:

- less than 18 years

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Genetic Mutations
By next generation sequencing

Locations
Country Name City State
Egypt Sherief Abd-Elsalam Cairo Tanta

Sponsors (1)
Lead Sponsor Collaborator
Tanta University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary number of patients with genetic polymorphism patients with abnormal polymorphisms 6 months
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