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Clinical Trial Summary

Open-label randomized controlled trial to test the effectiveness of whole blood transfusion for improving survival in children with severe malaria complicated by thrombocytopenia.


Clinical Trial Description

The PLATFORM trial is a single-center, open-label randomized controlled trial of whole blood transfusion for severe malaria complicated by thrombocytopenia. The trial will recruit 132 Zambian children 6 months to 15 years old with severe malaria defined according to modified WHO criteria with concomitant thrombocytopenia, defined here as a platelet count ≤75,000/uL, who do not otherwise have a current indication for transfusion according to current guidelines. Children will be randomized 1:1 to whole blood transfusion or no whole blood transfusion and followed to hospital discharge or death. The trial is nested within the Children and Adults with Severe Malaria (CHASM) cohort, a prospective observational study of severe malaria. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05711485
Study type Interventional
Source Johns Hopkins Bloomberg School of Public Health
Contact Matthew M Ippolito, MD PhD
Phone 443-287-4809
Email mippolito@jhu.edu
Status Recruiting
Phase N/A
Start date February 24, 2024
Completion date February 28, 2025

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