Thoracic Aortic Aneurysm Clinical Trial
— TAAOfficial title:
Identification of Genes and Pathogenesis Involved in Familial Thoracic Aortic Aneurysm (TAA)
Verified date | November 2017 |
Source | Assistance Publique - Hôpitaux de Paris |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The primary objectives of the study are
- to assess the contribution of alteration of each known gene on non-syndromic TAA.
- to map and identify unknown gene involved in the non-syndromic TAA.
Status | Completed |
Enrollment | 258 |
Est. completion date | March 2017 |
Est. primary completion date | December 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: For all: - Aged > 18 years. - Written informed consent obtained. - People with health insurance. For individual: - people = 45 years, thoracic aortic aneurysm without syndrome, - or people > 45 years with familial TAA. For family: - At least 2 members of family in 2 generations have TAA without syndrome and at least 2 patients of TAA will undergo blood collection. - All people in family will undergo blood collection, each member should declare at first his (her) status (with or without TAA, unknown), the relationship (direct relative family or family in-law), no limit of age. For the children, only those with TAA will perform blood collection for the study. Exclusion Criteria: - Thoracic aortic aneurysm with different syndromes (Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome, Turner syndrome, Noonan syndrome). - Arterial hypertension. |
Country | Name | City | State |
---|---|---|---|
France | Département de Génétique, Hôpital Bichat | Paris | Ile De France |
Lead Sponsor | Collaborator |
---|---|
Assistance Publique - Hôpitaux de Paris |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Impact of known mutations and research of new genes involved in non syndromic TAA | Research for mutations in known genes such as FBN1, TGFBR1, TGFBR2, ACTA2, or MYH11. Research for new genes in families and in individuals TAA patients without known mutation. |
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