The Effect of Losartan in Bicuspid Aortic Valve Patients

Status Recruiting

Clinical Trial Summary

The specific aims of this study are to:

- Establish baseline levels of circulating MMP-2 and -9 , TIMP-1and- 2 and TGFB levels in individuals with bicuspid aortic valve and ascending aortic or aortic sinus measurements >40mm.

- Assess the effect on MMP levels during treatment with losartan, an angiotensin II receptor blocking agent.

- In the setting of losartan therapy for one year, evaluate the response of MMP levels in these patients, and clinical outcomes including effects on aortic growth rate

Clinical Trial Description

n/a

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01390181
Study type	Interventional
Source	University of Michigan
Contact	Nickole L Carlson, BSN
Phone	734 232 4780
Email	ngarvey@med.umich.edu
Status	Recruiting
Phase	N/A
Start date	September 2011

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