Testicular Germ Cell Tumor Clinical Trial
Official title:
A Study of Paclitaxel, Cisplatin and Ifosfamide as Induction Therapy in the Treatment of Patients Relapsing After BEP Chemotherapy for Metastatic Germ Cell Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combining paclitaxel, ifosfamide, and
cisplatin in treating patients who have metastatic testicular cancer that has recurred
following treatment.
OBJECTIVES:
- Determine the feasibility of combining paclitaxel, ifosfamide, and cisplatin induction
in patients with metastatic nonseminomatous germ cell tumor of the testis in first
relapse following first line treatment with bleomycin, etoposide, and cisplatin.
- Determine the response rates to this regimen in these patients
OUTLINE: This is a multicenter study.
Patients receive paclitaxel IV over 3 hours and ifosfamide IV and cisplatin IV daily for 5
days. Patients with stable or responding disease repeat treatment every 3 weeks for 4
courses in the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: A minimum of 25 patients will be accrued for this study.
;
Primary Purpose: Treatment
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