Frontoparietal Priority Maps as Biomarkers for MTBI

TBI (Traumatic Brain Injury) Clinical Trial

Official title: Frontoparietal Priority Maps as Biomarkers for MTBI

Status Completed

Clinical Trial Summary

The purpose of this study is to determine whether there is a quantitative relationship between brain processes seen by a MRI and visual deficits caused by mild to moderate traumatic brain injuries (mTBI).

Clinical Trial Description

Participants with mTBI, as well as healthy control participants, will be invited to participate in up to two study visits. Both visits will occur at the University of Minnesota's Center for Magnetic Resonance Research (CMRR). The first study visit will entail (1) interviews to determine the presence of (and, if present, the severity of) oculomotor difficulties such as convergence insufficiency, and (2) behavioral measures (e.g., visually track a moving dot) to assess skill at allocating spatial attention. For participants who have not before participated in an MRI study at the CMRR, a 15-minute scan to acquire research-quality anatomical images of the brain will be acquired at the end of the first visit. A subset of the approximately 88 participants who participate in Visit 1 will be invited to participate in Visit 2. Visit 2 will be dominated by a 90-minute scanning session in the 7 Tesla scanner, during which participants will perform a 10-minute spatial attention task and a 10-minute eye movement task, and high-resolution diffusion tensor imaging data will be acquired while participants enjoy the movie of their choice in the scanner. ;

Related Conditions & MeSH terms

• Brain Injuries
• Brain Injuries, Traumatic
• Ocular Motility Disorders
• TBI (Traumatic Brain Injury)

• NCT number: NCT02251002
• Study type: Observational
• Source: University of Minnesota - Clinical and Translational Science Institute
• Status: Completed
• Start date: July 2015
• Completion date: October 2018