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Tardive Dystonia clinical trials

View clinical trials related to Tardive Dystonia.

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NCT ID: NCT02524886 Terminated - Tardive Dyskinesia Clinical Trials

Deep Brain Stimulation for Patients With Tardive Dyskinesia and or Dystonia

Start date: June 2015
Phase: N/A
Study type: Interventional

Rationale: Tardive dyskinesia and dystonia (TDD) are severe side effects of dopamine blocking agents, particularly antipsychotics. Deep brain stimulation (DBS) has shown to be effective in the treatment of TDD in psychiatric patients, but only reported in case reports and small clinical trials and with little attention to possible psychiatric or cognitive complications or positive effect on psychiatric symptoms. Objective: To assess whether treatment with DBS can reduce or resolve TDD and if DBS can induce beneficial or side-effects in particular psychiatric symptoms. Study design: A delayed onset double blind randomised controlled trial. Study population: Adult patients with a current or previous psychiatric disorder and antipsychotic induced TDD with a stable psychiatric status during the past 6 months. Intervention: All patients will be treated with DBS in the posteroventrolateral GPi. The groups will be randomised into immediate stimulation or delayed stimulation after 3 months. Main study parameters/endpoints: Primary objective, improvement on the movement rating scales BFMDRS. Secondary objectives improvement on the quality of life measured on the SF-36, psychiatric stability as measured on the BPRS and the MADRS and cognitive effects as measured on the MATTIS Dementia Rating Scale, Nederlandse Leestest voor Volwassenen (NLV), 15 word test, Facial Expression of Emotion S+T (FEEST), Groninger Intelligentie Test woordopnoemen (GIT), category and letter fluency test, Trail Making Test part A and B and the Stroop colour and word test

NCT ID: NCT02509338 Terminated - Tardive Dystonia Clinical Trials

Validation of the Implantation of a New Electrode for the Treatment of Dystonia

MONOCONTACT
Start date: October 2013
Phase: N/A
Study type: Interventional

The main objective of the trial is to study the technical feasibility of the implantation of a new electrode Monocontact deep brain stimulation electrode in dystonia.

NCT ID: NCT01921270 Completed - Tardive Dystonia Clinical Trials

Dysport for the Treatment of OMD

Start date: August 2013
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to study the efficacy and safety of AbobotulinumtoxinA (Dysport) for use in Oromandibular Dystonia (OMD).