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Tachypnea clinical trials

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NCT ID: NCT06278415 Recruiting - Clinical trials for Transient Tachypnea of the Newborn

Physiologically Based Cord Clamping To Improve Neonatal Outcomes After Elective Cesarean Delivery

PhyCord1
Start date: January 21, 2024
Phase: N/A
Study type: Interventional

Before birth, the baby's lungs are filled with fluid and babies do not use the lungs to breathe, as the oxygen comes from the placenta. As delivery approaches, the lungs begin to absorb the fluid. After vaginal delivery, the umbilical cord is clamped and cut after a delay that allows some of the blood in the umbilical cord and placenta to flow back into the baby. Meanwhile, as the baby breathes for the first time, the lungs fill with air and more fluid is pushed out. However, it does not always work out that way. Some babies need to be delivered via cesarean section, a surgical delivery requiring incisions through the abdominal and uterine walls. After cesarean section, the mother is often unable to hold the baby close right away as a result of her own post-surgical care. Moreover, a baby born by planned cesarean section may have breathing problems because of extra fluid staying in the lungs. Thus, the baby must breathe quicker and harder to get enough oxygen enter into the lungs. Although the baby is usually getting better within one or two days, the treatment requires close monitoring, breathing help, and nutritional help as the baby is too tired to suck and swallow milk. Sometimes, the baby cannot recover well and show greater trouble breathing needing intensive care. This further separates the mother and her baby. A possible mean to help the baby to adapt better after cesarean section while staying close to the mother is to delay cord clamping when efficient breathing is established, either spontaneously or after receiving breathing help at birth. In this study, we intend to test this procedure in term infants born by planned cesarean section and see whether the technique helps the baby to better adapt after birth and to better initiate a deep bond with the mother.

NCT ID: NCT06270823 Recruiting - Clinical trials for Transient Tachypnea of the Newborn

Reducing Respiratory Distress After Elective Caesarean Birth Through Knee-chest-flexion: a Randomized Controlled Trial

Start date: February 14, 2024
Phase: N/A
Study type: Interventional

Planned caesarean birth is a risk factor for the development of neonatal respiratory distress commonly known as transient tachypnoea of the newborn. This is due to the absence of labor physiology which facilitates the clearance of fetal lung fluid. We hypothesized that by mimicking flexion induced by uterine contractions by manually performing knee-to-chest flexion directly at birth to achieve expulsion of excess lung liquid, we could reduce the incidence of respiratory distress in term children born by planned CS. The goal of this clinical trial is to test whether performing a knee-to-chest flexion maneuver directly after elective caesarean section will decrease the incidence of respiratory distress in term infants when compared to the standard care

NCT ID: NCT05538780 Recruiting - Clinical trials for Transient Tachypnea of the Newborn

Diagnosis of Transient Tachypnea of Newborn

Start date: January 1, 2022
Phase:
Study type: Observational

Transient tachypnea of the newborn (TTN) is the most common cause of respiratory distress in fullterm newborn. TTN is a diagnosis of exclusion, It is primarily diagnosed based on medical history and typical clinical presentation. Lung ultrasonography is an accurate, non invasive and reliable tool for diagnosing TTN. Cardiometry is presently the only tool to evaluate thoracic fluid content continuously and noninvasively at the bedside.

NCT ID: NCT05527704 Recruiting - Respiratory Failure Clinical Trials

the Inhaled β2-adrenergic Receptor Agonist for Transient Tachypnoea of the Newborn (the REFSAL Trial)

REFSAL
Start date: December 31, 2021
Phase: Phase 3
Study type: Interventional

Clinical trial evaluating the efficacy and safety of salbutamol for the treatment of neonates with a gestational age between 32 and 42 weeks with transient tachypnoea of the newborn (TTN).

NCT ID: NCT04758078 Recruiting - Clinical trials for Respiratory Distress

Inhaled Budesonide in Transient Tachypnea of the Newborn

Start date: February 15, 2021
Phase: N/A
Study type: Interventional

Background: Transient tachypnea of the newborn (TTN) caused by lung edema resulting from delayed absorption of fetal alveolar lung fluid and is a common cause of admission of late preterm and full-term infants to neonatal intensive care units. Infant born by C-section and those with perinatal asphyxia, umbilical cord prolapse or certain maternal condition (asthma, diabetes, or analgesia) are more prone to develop TTN. Conventional treatment involves appropriate oxygen administration and continuous positive airway pressure in some cases. Hastening the clearance of lung liquid should shorten the duration of the symptoms and reduce complications. Objectives: This study aims to determine the effectiveness of inhaled budesonide in the treatment of this disorder through determining whether it reduces the duration of oxygen therapy and respiratory symptoms and shortens hospital stay in term infants with transient tachypnea of the newborn

NCT ID: NCT03346343 Recruiting - Clinical trials for Bronchopulmonary Dysplasia

Pulmonary Function Using Non-invasive Forced Oscillometry

PUFFOR
Start date: December 6, 2017
Phase: N/A
Study type: Interventional

The purpose of this observational study is to measure pulmonary function in term and preterm infants with and without pulmonary disease including respiratory distress syndrome, bronchopulmonary dysplasia, transient tachypnea of the newborn, meconium aspiration syndrome, and response to treatments given to newborn infants with lung diseases using a non-invasive airway oscillometry system.

NCT ID: NCT03031353 Recruiting - Clinical trials for Cesarean Delivery Affecting Fetus

Misoprostol Before Elective Caesarean Section for Decreasing the Neonatal Respiratory Morbidity

Start date: January 2017
Phase: N/A
Study type: Interventional

Neonatal respiratory distress may occur in either term or preterm newborns with a higher relative risk in preterm, and whether born vaginally or through caesarean section, but in a higher percentage after elective caesarean section whose rate is rising. Prostaglandins may be given about one hour before an elective caesarean section after excluding the presence of contraindication to their use to decrease the neonatal respiratory diseases and thus, the number of children who suffered from bronchopulmonary dysplasia that occurs frequently in children who had previously TTN will diminish.

NCT ID: NCT01858129 Recruiting - Clinical trials for Transient Tachypnea of the Newborn

Inhaled Corticosteroids for the Treatment of Transient Tachypnea of the Newborn

Start date: March 2012
Phase: Phase 2
Study type: Interventional

Transient Tachypnea of the Newborn (TTN) is a common respiratory disorder affecting late preterm and term babies caused by lung edema resulting from delayed absorption of fetal alveolar lung fluid. The investigators hypothesize that ENAC expression will be up-regulated as a result of administration of corticosteroids. This effect will lead to enhanced absorption of fetal lung fluid finally treating TTN. The aim of our study will be to evaluate whether inhaled corticosteroids reduce respiratory distress and morbidity in late preterm and term neonates presenting with TTN.

NCT ID: NCT01499238 Recruiting - Clinical trials for Transient Tachypnea of Newborn

Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn

Start date: December 2011
Phase: Phase 4
Study type: Interventional

The investigators aimed to compare the efficacy of nasal SIMV and nasal CPAP in patients with wet lung.

NCT ID: NCT01270581 Recruiting - Clinical trials for Transient Tachypnea of the Newborn

High Flow Nasal Cannula Versus Bubble Nasal CPAP for the Treatment of Transient Tachypnea of the Newborn in Infants ≥ 35 Weeks Gestation

Start date: July 2010
Phase: N/A
Study type: Interventional

The primary objective is to determine whether High Flow Nasal Cannula (HFNC) is a superior respiratory modality for neonates ≥36 weeks with transient tachypnea of the newborn (TTN) when compared to the standard of care modality (NCPAP).