T-Cell Lymphoma Clinical Trial
Official title:
A Pilot Study of Oncaspar® + Dexamethasone in Patients With Relapsed or Refractory T-Cell Lymphoma
This is an open-label, single-arm pilot study of Oncaspar® with dexamethasone for patients with relapsed or refractory peripheral T-cell lymphoma (PTCL), excluding extranodal NK/T cell lymphoma (ENKTL). Patients will receive up to 8 courses of treatment.
This is an open-label, investigator-initiated, single-arm pilot study. Patients with
relapsed or refractory (R/R) peripheral T-cell lymphoma (PTCL) will receive Oncaspar® every
3 weeks up to a maximum of 8 courses or until disease progression or unacceptable toxicity.
They will also receive dexamethasone 40mg daily for 4 days with every cycle. They will be
restaged after 2 courses (6 weeks) and after 8 courses (24 weeks).
Both Oncaspar and dexamethasone have been used together to treat ALL and ENKTL, which is
another subtype of T cell lymphoma. The combination may provide a collaborative attack
against the cancer cell; moreover, the dexamethasone could also prevent some of the side
effects of Oncaspar; especially allergic reactions. This study will test these two drugs
together to determine if they are an effective treatment for T-Cell Lymphoma. Each drug is
commercially available to the drug market.
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