Systolic Heart Failure Clinical Trial
Official title:
MRI Allocation of Pacing Targets in Cardiac Resynchronization Therapy
Magnetic Resonance Image guided delivery of Left and Right Ventricular Leads to optimal myocardial targets will result in improved clinical response to CRT using Left Ventricular remodeling criteria.
Cardiac Dyssynchrony and scar are important variables for realization of clinical response
to cardiac resynchronization therapy (CRT). Results from a previous study suggest that paced
heart segment characteristics do predict this response and our ability to identify venous
pathways to optimal segments is feasible using cardiac CT and MRI. In an ongoing feasibility
study we are using these capabilities to guide the delivery of CRT lead systems to optimal
myocardial targets. A computer software program has been developed that can create an
interactive, 3D integrated cardiac model of coronary vein anatomy, myocardial scar and
mechanical dyssynchrony. Although this feasibility study is ongoing, early results show this
method of guiding the CRT leads to optimal targets with these individualized models to be
safe and effective.
This trial will be a larger multi-centre randomized blinded trial to determine the
therapeutic impact of MRI guided Left Ventricular and Right Ventricular lead placement with
respect to improving clinical response rates for CRT.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
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