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Clinical Trial Summary

This is an investigator-initiated trial to evaluate the safety and efficacy of anti-CD19-CD3E-CAR-T cells in the relapse or refractory autoimmune diseases.


Clinical Trial Description

This is an investigator-initiated trial to evaluate the safety and efficacy of anti-CD19-CD3E-CAR-T cells in the relapse or refractory autoimmune diseases. Study intervention consists of a single infusion of CAR-transduced autologous T cells administered intravenously after a lymphodepleting therapy regimen consisting of fludarabine and cyclophosphamide. Interim analysis will be performed when participants finish the visit of 12 weeks after CAR-T cells infusion. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06373081
Study type Interventional
Source Shanghai Changzheng Hospital
Contact Huji Xu, Ph.D, MD
Phone 86021-81885514
Email xuhuji@smmu.edu.cn
Status Recruiting
Phase N/A
Start date April 20, 2024
Completion date April 15, 2026

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