Pulmonary Hypertension Screening for Rheumatology Patients (SOPHIE)

Systemic Lupus Erythematosus Clinical Trial

— PAH  

Official title:

Territory-Wide Pulmonary Hypertension Screening Amongst Patients With Connective Tissue Diseases: A Prospective Screening Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03446339
• Other study ID #: PH_Screening_1.4.2017 ver.1
• Status: Recruiting
• Start date: August 3, 2017
• Est. completion date: December 2023

Study information

• Verified date: August 2021
• Source: The University of Hong Kong
• Contact: David Chung-Wah Siu, Professor
• Phone: +852-22554694
• Email: cwdsiu[@]hku.hk
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Pulmonary arterial hypertension (PAH) is a serious and often fatal complication of connective tissue diseases including systemic sclerosis and systemic lupus erythematosus. It has been reported primarily from European series that the prevalence of PAH in patients with connective tissue diseases particularly systemic sclerosis is as high as 15-20%. However, given the paucity of medical literature in the area from Chinese population, the prevalence of PAH amongst Chinese patients with these conditions is largely unknown. Even worse, PAH is often undiagnosed amongst patients with connective tissue diseases due to the lack of awareness and/or access to echocardiography, which is a non-invasive first-line screening tool for PAH. As a result, most patients at diagnosis of PAH are at a relatively late stage, rendering pharmacological treatment less effective. Here, the investigators propose a territory-wide pulmonary hypertension screening for patients with connective tissue disease in order to (1) detect pulmonary hypertension amongst patients with connective tissue disease through systematic screening, and (2) understand the prevalence of pulmonary hypertension in Chinese patients with connective tissue diseases.

Description:

Objectives:

1. To detect pulmonary hypertension amongst patients with connective tissue diseases through systematic screening

2. To understand the prevalence of pulmonary hypertension in Chinese patients with connective tissue diseases

Study design:

The study is a territory-wide pulmonary hypertension screening project. Patients fulfilling the inclusion and exclusion criteria will undergo screen echocardiography as baseline to detect subclinical pulmonary hypertension.

Screening procedure:

Participants will undergo usual clinical assessment by the rheumatology teams of the parent hospitals including standard 12-lead ECG and 6-minute hall walk distance. then they will be referred to the Division of Cardiology, the Department of Medicine, the University of Hong Kong for (1) Echocardiography and (2) BNP (or pro-NT BNP) assay. The echocardiography will be performed based on the European Society of Cardiology (ESC)/European Respiratory Society (ERS) Guidelines. The echocardiographic probability of pulmonary hypertension will be determined (low, intermediate, and high).

Statistical analysis and power calculation:

There are no studies on which to calculate a power equation, because there are no previous reports on the prevalence of pulmonary hypertension in Chinese rheumatological patients. The sample size is based on our local prevalence of the rheumatological diseases.

Continuous variables will be expressed in mean ± SD. Statistical comparisons were performed using Student's t test or Fisher's exact test, as appropriate. The outcomes would be analyzed.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 1800
• Est. completion date: December 2023
• Est. primary completion date: August 31, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patientw with either (1) systemic lupus erythematosus, (2) systemic sclerosis, or (3) other connective tissue diseases at risk of pulmonary hypertension

• Voluntarily agrees to participate by providing written informed consent

• Age = 18 at enrolment

Exclusion Criteria:

• Refuse to participate the study

Related Conditions & MeSH terms

• Connective Tissue Diseases
• Hypertension
• Hypertension, Pulmonary
• Lupus Erythematosus, Systemic
• Scleroderma, Diffuse
• Scleroderma, Systemic
• Systemic Lupus Erythematosus
• Systemic Sclerosis

Locations

Country	Name	City	State
China	The University of Hong Kong	Hong Kong

Sponsors (1)

Lead Sponsor	Collaborator
The University of Hong Kong

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Prevalence of asymptomatic pulmonary hypertension in Chinese patients with connective tissue diseases	Proportion of patients diagnosed to have pulmonary hypertension	36 months
Secondary	Clinical predictor of Echocardiography for pulmonary hypertension in Chinese patients with connective tissue diseases	Cardiac functional and structural data for pulmonary hypertension detection	36 months
Secondary	Clinical predictor of BNP assay for pulmonary hypertension in Chinese patients with connective tissue diseases	Cardiac marker for cardiac problems indication	36 months