Systemic Infections Clinical Trial
Official title:
PROGNOSTIC HEMODYNAMIC PROFILING IN THE ACUTELY ILL EMERGENCY DEPARTMENT PATIENT
This multinational registry (3 USA, 2 European centers) will capture in the ED continuous non invasive hemodynamic monitoring (using Nexfin finger cuff technology) of patients presenting with acute heart failure, stroke syndromes and systemic infection. Patients will be observed after their Emergency Department (ED) disposition to determine clinical outcomes (length of stay in the hospital, the development of any organ dysfunction, mortality and need for unscheduled medical care within the ensuing 30 days). It is anticipated that specific ED hemodynamic profiles will be predictive of better clinical outcomes than others. This information will provide the outcome data needed to design future therapeutic trials that will evaluate the effect of ED hemodynamic manipulations on overall patient management and outcomes.
The PREMIUM Registry is a multinational, prospective, observational convenience study of the
ED hemodynamic profiles of patients presenting with acute CHF, stroke and systemic
infections and their potential relationship with patient outcomes. Continuous hemodynamics
will be measured by noninvasive means using the Nexfin device and outcomes (in hospital
length of stay, the interval development of organ dysfunction and mortality or the need for
unscheduled medical care within the ensuing 30 days) will be captured within the registry.
The treating ED physicians will be blinded to the hemodynamic monitoring and there will be
no modification of the standard care that each patient receives. Hospital charts will be
reviewed and patients/family members will be additionally called at 30 days after the
hospital visit in order to collect any additional outcome data.
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Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01893346 -
Safety and Tolerability of Ceftazidime-Avibactam for Pediatric Patients With Suspected or Confirmed Infections
|
Phase 1 |