Sympathetic Nerve Activity Clinical Trial
Official title:
Noninvasive Measurement of Sympathetic Nerve Activity in Healthy Volunteers
Activation of the sympathetic nervous system is associated with increased risk of ventricular
arrhythmias and sudden cardiac death (SCD). Development of simple, noninvasive, reliable
tools to measure sympathetic outflow in human subjects is therefore highly desirable.
Microneurography is the current gold standard measurement technique, whereby multiunit
postganglionic sympathetic nerve activity is recorded with tungsten ultrafine microelectrodes
inserted selectively into nerve fascicles of the peroneal nerve. Though this technique is
considered extremely safe, and has been used successfully for decades in human translational
physiology experiments, it has not been adopted for routine clinical assessment due to the
requirement for sophisticated equipment and specific technical training and skills.
Alternatively, many have adopted heart rate variability as a simple, noninvasive technique
for assessing sympathetic nerve activity. However, heart rate variability does not directly
measure sympathetic nerve activity, and there is much debate in the literature as to the
exact source of sympathetic nerve traffic. For example, many believe it is an accurate
reflection of cardiac sympathetic nerve activity, but does not accurately reflect changes in
muscle or skin sympathetic nerve activity.
To address these limitations, the investigators have developed a simple, noninvasive
technique to measure sympathetic nerve activity using surface electrodes.
Despite its great promise, this new approach has not yet been directly validated. The purpose
of this study is therefore to validate this new technique (refered to as EKG-NA) against the
current gold standard measurement technique, microneurography.
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