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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT01273792
Other study ID # Biomarkers Susac Syndrome
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date May 2010
Est. completion date December 2021

Study information

Verified date July 2021
Source Charite University, Berlin, Germany
Contact Jan M Dörr, MD
Phone +49 30 450
Email jan-markus.doerr@charite.de
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Susac Syndrome is a rare disease and the establishment of the diagnosis is often difficult. The aim of this investigation is to identify relevant biomarkers and to elucidate the pathogenesis of Susac syndrome


Description:

Susac Syndrome is a rare disease characterized by encephalopathy, branch retinal artery occlusion and sensorineural deafness. The pathogenesis is not yet clear, an autoimmune endotheliopathy is discussed. Because of the variable and often incomplete clinical presentation, the establishment of the diagnosis is often delayed or even completely missed. The aim of this study is to identify biomarkers that facilitate the reliable and prompt establishment of the diagnosis. Patients with a definite diagnosis of Susac syndrome and healthy subjects as controls are investigated. Furthermore, the correlation of serological markers with structural retinal and cerebral changes will contribute to clarification of the pathogenesis of Susac syndrome.


Recruitment information / eligibility

Status Recruiting
Enrollment 30
Est. completion date December 2021
Est. primary completion date December 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - adult male and female patients with definite Susac syndrome or matching healthy control subjects - ability to provide informed consent Exclusion Criteria: - pregnancy

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
Germany NeuroCure Clinical Reserach Center, Charité Universitaetsmedizin Berlin

Sponsors (1)

Lead Sponsor Collaborator
Charite University, Berlin, Germany

Country where clinical trial is conducted

Germany, 

References & Publications (1)

Dörr J, Radbruch H, Bock M, Wuerfel J, Brüggemann A, Wandinger KP, Zeise D, Pfueller CF, Zipp F, Paul F. Encephalopathy, visual disturbance and hearing loss-recognizing the symptoms of Susac syndrome. Nat Rev Neurol. 2009 Dec;5(12):683-8. doi: 10.1038/nrneurol.2009.176. — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary disease specific patterns of pathology on cranial MRI one-time cranial MRI
Primary disease specific patterns of pathology in optical coherence tomography one time optical coherence tomography
Primary serological biomarkers not defined, cross-sectional analysis
See also
  Status Clinical Trial Phase
Completed NCT06349603 - Physiotherapy Approach for Susac Syndrome