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Surgical Wound Infection clinical trials

View clinical trials related to Surgical Wound Infection.

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NCT ID: NCT06402591 Active, not recruiting - Clinical trials for Surgical Site Infection

Results of Extended Versus Single Dose Antibiotic Prophylaxis In Orthopedic Revision Arthroplasty in Nijmegen.

REViSION
Start date: January 1, 2019
Phase: Phase 3
Study type: Interventional

The goal of this randomized control trial is to investigate the superiority of 5 days (extended) versus a single dose of cefazolin prophylaxis in revision arthroplasty of the hip and knee. The main question[s] it aims to answer are: - Is an extended regimen compared to a single dose of cefazolin associated with an increased infection-free implant survival within one year after index revision arthroplasty of the hip or knee? - What are the incidence, risk factors, treatment outcome and prognosis of surgical site infections and periprosthetic joint infection during follow-up? - What is the safety and tolerance of the antimicrobial prophylaxis regimens used? - What are the antimicrobial susceptibility patterns of micro-organisms causing PJI during follow-up? - What is the patient' physical performance and satisfaction of subjects within 1 year after the index revision arthroplasty, using patient related outcome measurements (PROMS)? [question 2] Participants will [describe the main tasks participants will be asked to do, treatments they'll be given and use bullets if it is more than 2 items]. If there is a comparison group: Researchers will compare [insert groups] to see if [insert effects].

NCT ID: NCT06048692 Active, not recruiting - Clinical trials for Cesarean Section; Infection

Cefepime and Unictam on Preventing Post-Cesarean Surgical Site Infections

Start date: January 1, 2023
Phase: Phase 3
Study type: Interventional

the aim of this study is to evaluate the efficacy of employing cefepime (CFM) versus ampicillin/sulbactam (AMS) in lowering the rate of post-cesarean surgical site infections.

NCT ID: NCT05873049 Active, not recruiting - Clinical trials for Infection, Surgical Site

Use of Real-time Fluorescence Imaging in Diabetic Foot Ulcers: the Impact of Colonization

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

The study evaluates the efficacy of fluorescence-guided de-colonization in patients with non-infected diabetic foot ulcers. The efficacy will also be compared between those who used artificial dermis and split-thickness skin graft for reconstruction surgery.

NCT ID: NCT05210556 Active, not recruiting - Clinical trials for Surgical Site Infection

Oral Antibiotic Bowel Preparation in Gynecologic Oncology Surgery

Start date: December 22, 2021
Phase:
Study type: Observational

The purpose of this study is to investigate whether the use of a preoperative antibiotic bowel regimen is associated with a reduced risk of deep organ/space surgical site infection in gynecologic oncology surgery.

NCT ID: NCT05158322 Active, not recruiting - Clinical trials for Surgical Site Infection

Effectiveness of the Decolonization Circuit of S. Aureus, Reducing Infection in Primary Arthroplasty of the Lower Limb

Start date: October 14, 2021
Phase:
Study type: Observational [Patient Registry]

Lower limb joint replacement surgery is one of the most prevalent globally. In our center, more than 400 lower limb arthroplasties (LLA) are performed annually. Developing a Surgical Site Infection (SSI) after (LLA) increases morbidity, mortality and healthcare costs. Staphylococcus aureus is the main causative agent of SSI and especially in LLA. One third of the population is a nasal carrier of Staphylococcus aureus, being a risk factor for patients who have to undergo knee replacement or hip replacement. Several studies have confirmed that the detection of S. aureus carriers and their subsequent decolonization reduces SSI rates

NCT ID: NCT05090176 Active, not recruiting - Clinical trials for Efficacy Povidone Soaked Suture in Reducing Surgical Site Infection

Title: Povidone-soaked Sutures Versus Ordinary Sutures for Reducing Surgical Site Infection

Start date: November 2, 2020
Phase: N/A
Study type: Interventional

To determine efficacy of using 3 minutes povidone-soaked suture in reducing surgical site infection during wound closure in elective surgery.

NCT ID: NCT04828304 Active, not recruiting - Diabetic Foot Ulcer Clinical Trials

PLASOMA Ultimate Safety & Efficacy Study

PULSE
Start date: May 26, 2021
Phase: N/A
Study type: Interventional

The purpose of the PULSE study are the followingL A.To perform post market clinical follow up (PMCF) on safety and efficacy: 1. Safety: To confirm transient short-terms side effects and verify long-term/outstanding risks. 2. Efficacy: To confirm the performance of PLASOMA, i.e. the beneficial effect on bacterial load. B. Determine the effect of PLASOMA on wound surface area. A secondary purpose is to examine the beneficial effects of PLASOMA on wound healing and to perform a health technology assessment (HTA). This clinical study will be an open label two-armed randomized controlled trial (RCT), performed at at least three sites (multi-center) in the Netherlands. The two arms are: 1. Control group: Standard wound care for 12 weeks or until healing, whichever occurs first; 2. Treatment group: Standard wound care + PLASOMA treatment for 12 weeks or until healing, whichever occurs first. The frequency of PLASOMA treatment will be determined by the treating (para)medical professional based on the number of visits they would schedule for the standard wound care at the study site. For all study subjects, the treatment frequency will be at least once per week (in order to have enough treatments for safety evaluation) and should not exceed once per day. Follow up (FU) will be performed at three timepoints for both arms: - FU1: 2 weeks after end treatment period - FU2: 12 weeks after end treatment period - FU3: 12 months after start treatment.

NCT ID: NCT04366440 Active, not recruiting - Clinical trials for Surgical Site Infection

De-Implementation of Unnecessary Surgical Antibiotic Prophylaxis in Children

OPerAtiC
Start date: November 1, 2020
Phase: N/A
Study type: Interventional

The overall objective of this study is to identify the best strategy to eliminate unnecessary antibiotic use after surgery in pediatric surgical procedures considered low-risk for an SSI. Based on literature and our preliminary data suggesting surgeons will not fully accept standardized order sets based on current guidelines, the investigators hypothesize that order set modification combined with ASP facilitation will outperform standard order set modification alone in de-implementing unnecessary postoperative antibiotic use.

NCT ID: NCT04281667 Active, not recruiting - Colorectal Cancer Clinical Trials

Mechanical Bowel Preparation and Oral Antibiotics Versus Mechanical Bowel Preparation Only Prior Rectal Surgery

MOBILE2
Start date: March 18, 2020
Phase: Phase 4
Study type: Interventional

MOBILE2 is a randomized controlled trial comparing mechanical and oral antibiotic bowel preparation to mechanical bowel preparation only in patients undergoing anterior rectal resection with primary anastomosis. Primary endpoint is Comprehensive Complication Index within 30 days from surgery.

NCT ID: NCT04096885 Active, not recruiting - Clinical trials for Surgical Site Infection

The Inselspital Surgical Cohort Study

InSurg
Start date: September 9, 2019
Phase:
Study type: Observational [Patient Registry]

Personalizing surgical care is of enormous clinical relevance, when considering the number of patients undergoing surgery in Switzerland every year. Currently, personalization is based on underlying or coexisting disease or alterations of laboratory values, but there is no accepted biological test available that may predict success or failure of surgery. Surgical site infections are the most common form of hospital-acquired infections. While the relevance of bacteria, antibiotics and intensive care support is well accepted, the impact of the individual host response remains poorly understood. The Investigators hypothesize that postoperative alterations of the metabolome allow identification of predictors of surgical complications in general, and surgical site infections in particular.