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INtestinal Dysbiosis and TRanslocation of Bacteria in Patients Undergoing Surgery — INTRA  

Surgical Site Infection Clinical Trial

Official title:
Analysis of INtestinal Dysbiosis and TRanslocation of Bacteria in Patients Undergoing Abdominal Surgery

Clinical Trial Summary

The goal of this observational study is to contribute to a better understanding of the perioperative kinetics of intestinal microbial composition and association with surgical site infections. The main question this study aims to determine if: - Patients undergoing surgery develop transient intestinal dysbiosis - Such transient dysbiosis is associated with translocation to the systemic circulation and surgical site infection Patients undergoing elective abdominal surgery will be included prospectively. Informed consent will be obtained. From patients the following information and samples will be collected: - Perioperative: Baseline health data, nutrition data, measurement body composition, glucose monitoring - Intraoperatively: - Mucosal swabs - Blood from central venous catheter and portal vein - Mesenteric lymph node - Intestinal specimen - Bile - Subcutaneous biopsy - Postoperatively: - If a surgical site infection occurs samples from infected site

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05775341
Study type Observational [Patient Registry]
Source Insel Gruppe AG, University Hospital Bern
Contact Guido Beldi, MD, Prof
Phone +41 31 632 48 18
Email guido.beldi@insel.ch
Status Recruiting
Phase
Start date February 27, 2023
Completion date December 31, 2026
View Details
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