Analysis of the Causes of Redo Pull-through for Recurrent Constipation and the Risk Factors Affecting the Prognosis of the Hirschsprung's Disease and Allied Disorders

Surgery Clinical Trial

Official title:

Analysis of the Causes of Redo Pull-through for Recurrent Constipation and the Risk Factors Affecting the Prognosis of the Hirschsprung's Disease and Allied Disorders

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06175598
• Other study ID #: TJ-IRB20230739
• Status: Completed
• Start date: December 1, 2023
• Est. completion date: December 7, 2023

Study information

• Verified date: December 2023
• Source: Tongji Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The goal of this observational study is to conducted a comprehensive analysis of the factors contributing to redo- Pull-through surgery for constipation recurrence in Children who are suffering from Hirschsprun' s disease (HSCR) and its allied disorders (ADHD) . The main question[s] it aims to answer are:

1. Our study focused on the treatment and prognosis of these conditions, drawing upon 16 years of patient data and clinical experiences"

2. What are the key risk factors affecting the prognosis of recurrent constipation patients undergoing repeat PT?

Recruitment information / eligibility

• Status: Completed
• Enrollment: 79
• Est. completion date: December 7, 2023
• Est. primary completion date: December 7, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

1. Patients admitted to the department of pediatric surgery at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, between January 2005 and December 2021;

2. HSCR and ADHD patients admitted due to "constipation recurrence" and requiring redo-PT.

Exclusion Criteria:

1. Patients undergoing staged surgeries or undergoing internal sphincterotomy;

2. Patients with concomitant severe congenital anomalies such as Down syndrome; (3) Patients with incomplete postoperative follow-up data after redo-PT.

Related Conditions & MeSH terms

• Constipation
• Hirschsprung Disease
• Pediatric ALL
• Surgery

Locations

Country	Name	City	State
China	Department of Pediatric Surgery	Wuhan	Hubei

Sponsors (1)

Lead Sponsor	Collaborator
Feng Jiexiong

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Participants with redo-pull-through surgery for recurrent constipation	After utilizing the terms "Hirschsprung" and "Redo pull-through" in searches across "PubMed" and "Web of Science" for references published between 1990 and 2023, and subsequent removal of duplicate and incomplete documents, we compiled clinical information from the remaining literature. This compilation facilitated a review of relevant literature on the causes of redo-PT for recurrent constipation, enabling an assessment of classification types, which we categorized into five groups: Incomplete Resection of Affected Intestinal Segments (IRAIS), Acquire Aganglionosis (AA), Intestinal Dysmotility (ID), Anastomotic Complications (AC), and Intestinal Neurodevelopmental Impairment (INI).	1990-2023
Primary	Participants with and without postoperative complications	Group the data by gender, age groups, surgical techniques, and surgical approaches. Then, calculate the number of cases with and without postoperative complications	through study completion, an average of 33 year