Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT05444036 |
Other study ID # |
NIRVANA 2 |
Secondary ID |
|
Status |
Completed |
Phase |
Phase 1
|
First received |
|
Last updated |
|
Start date |
September 1, 2018 |
Est. completion date |
June 1, 2019 |
Study information
Verified date |
June 2022 |
Source |
Egymedicalpedia |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
Because pain is difficult to measure in children, post-operative pain is frequently
undertreated in this age range. Pain treatment is required in children due to the high
emotional component of pain. Pain is a multidimensional, subjective, perceptual event having
a variety of qualities such as intensity, quality, time course, and effects that are
perceived differently by each person. Because the operational definition of pain necessitates
self-report, pain experienced by children and babies is frequently overlooked, if not
ignored.
When general anesthesia is paired with regional procedures, children of all ages are exposed
to less intravenous and inhalational anesthetics and analgesics, leaving them nearly free of
nausea, vomiting, itching, or unneeded drowsiness. Being completely awake and able to drink
soon after surgery, as well as having no issues breathing even after lengthy surgery, are
significant benefits that children and parents value.
Description:
Caudal block provides the potential benefit of extending the length and effectiveness of the
block by combining additional medications with the local anaesthetic agent. Morphine,
clonidine, ketamine, and midazolam were among the drugs used.
Although peripheral nerve blocks and caudal anesthesia are relatively safe, extreme attention
is required to minimize adverse consequences. Pediatric anesthesiologists must have adequate
training to ensure patient safety. A well-trained pediatric anesthesiologist will try to
avoid unsafe regional anesthetic application methods and will always be prepared to manage
dangerous side effects (overdoses, intravenous administration induced seizures, tip
displacement of epidural catheters or centrally located abscesses).
Ketamine is a non-competitive N-methyl D-aspartate NMDA receptor antagonist that is thought
to prevent or reverse central sensitization and, as a result, lessen postoperative pain. It
also has a peripheral analgesic effect.
Ketamine infiltration has been demonstrated to provide pain alleviation in children having
adenotonsillectomy for up to 24 hours following surgery with no adverse effects.