Surgery Clinical Trial
Official title:
Influence of the End-inspiratory Pause on Mechanical Ventilation and Its Correlation With Electrical Impedance Tomography
This study evaluates the influence of two different end-inspiratory pause (EIP) times on respiratory mechanics and arterial gases of surgical patients when ventilated under an open lung approach (OLA) strategy. The investigators evaluate the impact of using EIP 10% versus 30% of the inspiratory time on a volume control model. The investigators also analyse the potential influence of these EIP on pulmonary gas distribution measured by electric impedance tomography.
Status | Completed |
Enrollment | 32 |
Est. completion date | July 30, 2018 |
Est. primary completion date | June 30, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 99 Years |
Eligibility |
Inclusion Criteria: - Patients older than 18 years proposed for major abdominal surgery under general anesthesia. - Written informed consent. Exclusion Criteria: - Participation in another interventional study - American Society of Anesthesiologists (ASA) classification grade = IV - Patient in dialysis - Chronic obstructive pulmonary disease (COPD) grade GOLD (Global Initiative for Chronic Obstructive Lung Disease) > 2 - Functional vital capacity < 60% or > 120% of the predicted - Body mass index (BMI) > 35 kg/m2 - Relation PaO2/FiO2 <200 mmHg in the baseline sample - Presence of mechanical ventilation in the 72 hours prior to enrollment - New York Heart Association (NYHA) functional class = 3 - Clinically suspected heart failure - Cardiac Index (IC) < 2.5 ml/min/m2 and/or inotropics prior to surgery - Diagnosis or suspicion of intracranial hypertension - Presence of pneumothorax or giant bullae on preoperative imaging tests - Use of Continuous Positive Airway Pressure (CPAP). |
Country | Name | City | State |
---|---|---|---|
Spain | Fundación Pública Andaluza para la Gestión de Investigación de Salud en Sevilla | Seville |
Lead Sponsor | Collaborator |
---|---|
Fundación Pública Andaluza para la gestión de la Investigación en Sevilla |
Spain,
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* Note: There are 17 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Changes in Respiratory System Compliance (ml/cmH2O) | Measurement of the respiratory system compliance (Crs; ml/cmH2O) when using an EIP of 10% versus 30% of the global inspiratory time. | Moment 0 (M0): 5 minutes (min) after tracheal intubation, with volume control and PEEP of 5 cmH2O; M1: 5 min after alveolar recruitment maneuver (ARM); M2: 5 min after crossing time of EIP; M3: 5 min after new ARM; M4: 5 min after crossing time EIP | |
Secondary | Changes in Driving Pressure (Pdriv; cmH2O) | Measurement of the Pdriv (cmH2O) when using an EIP of 10% versus 30% of the global inspiratory time. | Moment 0 (M0): 5 minutes (min) after tracheal intubation, with volume control and PEEP of 5 cmH2O; M1: 5 min after alveolar recruitment maneuver (ARM); M2: 5 min after crossing time of EIP; M3: 5 min after new ARM; M4: 5 min after crossing time EIP |
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