Surgery Clinical Trial
Official title:
The Impact of Lowering Transfusion Trigger on Patient Immune Response During Major Abdominal Surgery
- We have previously reported the results of the primary and secondary outcomes of a
randomized study aiming to investigate the impact of a restrictive transfusion protocol
on the magnitude of reduction in blood transfusion in a typically mixed general surgery
population subjected to major abdominal surgery.
- The main finding of that study was a reduction in red blood cell usage with the
implementation of a restrictive transfusion regimen. This was achieved without adversely
affecting clinical outcome in the population studied.
- The aim of this secondary analysis performed on a subgroup of 20 patients from the
original study was to determine whether there are any differences in the postoperative
immunologic response, as expressed by the production of inflammatory mediators, between
a restrictive approach to red cell transfusion and a more liberal strategy.
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