Sodium Bicarbonate Supplementation in Combat Sports Athletes

Supplementation Clinical Trial

Official title:

The Effect of Sodium Bicarbonate Supplementation on Physical and Specific Performance Capacity in Combat Sports Athletes

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03406065
• Other study ID #: ULS00003
• Status: Completed
• Phase: Phase 2/Phase 3
• First received: January 14, 2018
• Last updated: January 14, 2018
• Start date: October 10, 2014
• Est. completion date: April 5, 2015

Study information

• Verified date: January 2018
• Source: Poznan University of Life Sciences
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study was to verify the effect of 10-day sodium bicarbonate (NaHCO3) and placebo (PLA) supplementation on physical and specific performance capacity, as well as concentrations of the selected biochemical blood markers in trained combat sports athletes, in a randomised, double-blind, placebo-controlled trial.

Description:

Sodium bicarbonate (NaHCO3) was proposed as an ergogenic agent, because it improves high-intensity and resistance exercise performance. Until now the major limitation to NaHCO3 supplementation has been the gastrointestinal (GI) side effects. Therefore, this study aims to examine the effect of chronic, progressive-dose NaHCO3 ingestion on physical capacity and specific performance capacity, and concentrations of the selected biochemical blood markers in trained combat sports athletes, in a randomised, double-blind, placebo-controlled trial.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 64
• Est. completion date: April 5, 2015
• Est. primary completion date: January 20, 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 17 Years to 30 Years

Eligibility

Inclusion Criteria:

• written informed consent from all participants before the study (included aslo informed consents to the participation in the study of athletes under the age of 18 obtained from their parents)

• a current medical clearance to practice sports,

• training experience: at least 4 years (of combat sport training),

• minimum of 4 workout sessions (combat sport) a week,

Exclusion Criteria:

• current injury,

• any health-related contraindication,

• declared general feeling of being unwell,

• unwilling to follow the study protocol.

Related Conditions & MeSH terms

• Sport
• Supplementation

Intervention

Dietary Supplement:
• Sodium bicarbonate supplementation
The experimental procedure for each athlete included a 10-day NaHCO3 supplementation in a progressive-dose regimen in order to reduce the likelihood of gastrointestinal side effects (from 25 to 100 mg · kg-1). NaHCO3 was administered in the form of unmarked disk-shaped tablets (Alkala T, SANUM, Poland). The tablets were ingested with at least 250 mL of water and could be either swallowed or dissolved in the mouth. On training days the supplements were taken in the morning, in the evening and 1.5 hours before training session. On rest days the supplements were taken in the morning, in the afternoon and in the evening.
• Placebo treatment
The experimental procedure for each athlete included a 10-day placebo administration. Placebo was ingested with at least 250 mL of water. On training days the supplements were taken in the morning, in the evening and 1.5 hours before training session. On rest days the supplements were taken in the morning, in the afternoon and in the evening.

Locations

Country	Name	City	State
Poland	Poznan University of Life Sciences, ul.Wojska Polskiego 31	Poznan	Wielkopolska

Sponsors (2)

Lead Sponsor	Collaborator
Poznan University of Life Sciences	Department of Biochemistry, Poznan University of Physical Education, Poland

Country where clinical trial is conducted

Poland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in anaerobic capacity after sodium bicarbonate supplementation	The Wingate Anaerobic Test (WAnT)	Baseline and after 10 days
Primary	Changes in specific performance capacity after sodium bicarbonate supplementation	The wrestler's special endurance test - projective test with dummy (DT)	Baseline and after 10 days
Secondary	Changes of lactate and pyruvate concentration in blood after sodium bicarbonate supplementation	Lactate [mmol/L] and pyruvate [mmol/L] concentration analysis	Baseline and after 10 days
Secondary	Changes of creatine kinase and lactate dehydrogenase activity in blood after sodium bicarbonate supplementation	Creatine kinase [U/L] and lactate dehydrogenase [U/L] activity analysis	Baseline and after 10 days
Secondary	Changes in blood glucose and hemoglobin concentration after sodium bicarbonate supplementation	Hemoglobin (Hb) [g/dl] and glucose [g/dl] concentration analysis	Baseline and after 10 days
Secondary	Changes in blood hematocrit levels after sodium bicarbonate supplementation	Hematocrit (HCT) [%] level analysis	Baseline and after 10 days
Secondary	Changes of red and white blood cell concentration in blood after sodium bicarbonate supplementation	Red blood cells (RBC) [mln/mm³] and white blood cells (WBC) [mln/mm³] concentration analysis	Baseline and after 10 days
Secondary	Changes in polyphenols and albumin concentration	Polyphenols [g/L] and and albumin [g/L] concentration analysis	Baseline and after 10 days
Secondary	Changes in FRAP concentration	FRAP [µmol/L] concentration analysis	Baseline and after 10 days