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The Impact of Ketamine on the Reward Circuitry of Suicidal Patients

Suicide Clinical Trial

Official title:
The Impact of Ketamine on the Reward Circuitry of Suicidal Patients: An MRI Study

Clinical Trial Summary

Every 40 seconds, someone in the world dies by suicide. There is a lack of effective and safe antisuicidal agents for preventing suicide attempts. This leads to the immense worldwide individual, financial, and societal burden of suicide—which is projected to rise in the coming decades—supporting the need for antisuicidal treatments.

This treatment gap may be filled through understanding the neurobiology of suicide, which can guide the development of targeted antisuicidal treatments. Though some research has examined the neurobiology of suicidal ideation in the context of depression—implicating the orbital frontal cortex, anterior cingulate cortex, and striatum—the underlying pathophysiology and neurobiology of suicidal ideation as a separate construct from depression remains largely unknown. Therefore, the investigators propose to study the neurocircuitry of suicidal thoughts, regardless of whether or not depression is present.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02532153
Study type Interventional
Source Massachusetts General Hospital
Contact
Status Withdrawn
Phase Phase 3
Start date February 2017
Completion date February 28, 2017
View Details
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