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Effect of Genetic Alterations in Key Genes in the Kynurenine Pathway on Suicidal Behavior — SuiKYN  

Suicidal Behavior Clinical Trial

Official title:
A Study on Genetic Alterations (Polymorphism) in Key Genes in the Kynurenine Pathway on Suicidal Behavior

Clinical Trial Summary

Current research has shown that an imbalance in the Kinurenine pathway plays a role in the physiopathology of neurogenerative and mental disorders (with a decrease in neuroprotective metabolites and an increase in neurotoxic products). So far the research has concentrated on the enzymes IDO, KAT, KMO, 3HAO and QPRT which are the key players in this pathway. Several polymorphisms affecting these enzymes have been associated with certain disorders characterized by a deregulation of the inflammation and immune response (McCauley et al 2009,Tardito et al 2013, Lee et al 2014), but no studies have ever tried to find a link between these enzymes and suicidal behavior. The investigators hypothesize that people who have attempted to commit suicide will have pro-inflammatory genetic variations affecting the kynurenine pathway.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04565834
Study type Observational
Source Centre Hospitalier Universitaire de Nimes
Contact Jorge LOPEZ-CASTROMAN, Professor
Phone +33466683897
Email Jorge.lopezcastroman@chu-nimes.fr
Status Recruiting
Phase
Start date December 1, 2019
Completion date September 1, 2022
View Details
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