Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men

Substrate Oxidation Clinical Trial

Official title:

Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01888991
• Other study ID #: CIHR kids_26570
• Secondary ID: CIHR MOP-111250
• Status: Completed
• Phase: N/A
• First received: June 22, 2013
• Last updated: June 25, 2013
• Start date: December 2011
• Est. completion date: August 2012

Study information

• Verified date: June 2013
• Source: University of Toronto
• Contact: n/a
• Is FDA regulated: No
• Health authority: Canada: Ethics Review Committee
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to investigate the effect of substrate oxidation, expressed by RER, on food intake regulation and net energy balance.

Description:

The relationship between substrate oxidation as measured by respiratory exchange ratio (RER) and food intake is undefined. This study is examining the effects of three modulators of substrate oxidation (RER), a glucose preload, exercise and age food intake regulation and net energy balance in normal-weight boys (9-12 y) and men (20-30 y).

Subjects (15 boys, 15 men) were measured in random order with treatments of beverages of either water or glucose followed by either moderate exercise or rest for 40 min. Measures included RER via indirect calorimetry, energy expenditure, subjective appetite, food intake measured at an ad libitum pizza meal and net energy balance as the sum of the calories of the glucose preload + calories from the pizza lunch minus energy expended at exercise or rest.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: August 2012
• Est. primary completion date: August 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 9 Years to 29 Years

Eligibility

Inclusion Criteria:

• Born at full term

• Men Age:20-29 years/BMI: 20-25

• Boys Age 9-11/BMI percentile: 15th to 85th:

Exclusion Criteria:

• Smokers

• Dieters

• Individuals with lactose intolerance, allergies to milk and dairy products

• Individuals with gastrointestinal problems

• Individuals with diabetes or other metabolic diseases

• Individuals scoring = 11 on an Eating Habit Questionnaire

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Food Intake Regulation
• Substrate Oxidation

Intervention

Other:
• Glucose Preload and Exercise Intervention
A glucose preload and exercise were administered to examine the modulate substrate oxidation

Locations

Country	Name	City	State
Canada	Department of Nutritional Sciences, University of Toronto	Toronto	Ontario

Sponsors (2)

Lead Sponsor	Collaborator
University of Toronto	Canadian Institutes of Health Research (CIHR)

Country where clinical trial is conducted

Canada, 

References & Publications (3)

Bellissimo N, Thomas SG, Goode RC, Anderson GH. Effect of short-duration physical activity and ventilation threshold on subjective appetite and short-term energy intake in boys. Appetite. 2007 Nov;49(3):644-51. Epub 2007 Apr 22. — View Citation

Bozinovski NC, Bellissimo N, Thomas SG, Pencharz PB, Goode RC, Anderson GH. The effect of duration of exercise at the ventilation threshold on subjective appetite and short-term food intake in 9 to 14 year old boys and girls. Int J Behav Nutr Phys Act. 2009 Oct 9;6:66. doi: 10.1186/1479-5868-6-66. — View Citation

Tamam S, Bellissimo N, Patel BP, Thomas SG, Anderson GH. Overweight and obese boys reduce food intake in response to a glucose drink but fail to increase intake in response to exercise of short duration. Appl Physiol Nutr Metab. 2012 Jun;37(3):520-9. doi: 10.1139/h2012-038. Epub 2012 Apr 25. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Food Intake	Energy intake from the ad libitum the pizza meal at 60 min was calculated based on the weight consumed and the compositional information provided by the manufacturer.	60 - 90 min in the study	No
Secondary	Net Energy Balance	Will be calculated from the energy consumed by the glucose preload and the pizza meal minus energy expended at the exercise.	0-90 min in the study	No