Substance-related Disorders Clinical Trial
Official title:
Cholesterol and Fatty Acids in Cocaine Addiction Relapse
Many substance dependent individuals continue to abuse a variety of substances during treatment for their disorder. Often, substance dependent individuals are co-diagnosed with depression and violence problems. Supplements of n-3 polyunsaturated fatty acids (PUFAs) may play a role in treating individuals with such substance abuse problems. The purpose of this study is to evaluate the effectiveness of the n-3 PUFAs eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA) in treating relapse, aggression, and depression in substance dependent individuals.
Past research suggests that low levels of some PUFAs play a role in the pathophysiology of
depressive and aggressive disorders. In addition, there is also evidence that PUFAs play a
role in treating substance dependent individuals. The purpose of this study is to determine
the efficacy of EFA and DPA in treating substance dependent individuals.
Participants will be randomly assigned to receive either 3 grams of n-3 PUFAs or placebo.
Treatment will last 3 months, followed by an observation period of 3 months. Study visits
will occur monthly and will last approximately one hour. Study visits will include blood
tests and a physical exam. Throughout the study, participants will continue to receive
standard substance abuse treatment and will complete urine tests at regular intervals.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment
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