Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00000388
Other study ID # U01MH050453
Secondary ID U01MH050453MH504
Status Completed
Phase Phase 4
First received November 2, 1999
Last updated September 28, 2015
Start date September 1998
Est. completion date November 1999

Study information

Verified date September 2015
Source New York University School of Medicine
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Interventional

Clinical Trial Summary

This trial is a continuation of the Multimodal Treatment Study of Children with Attention Deficit Hyperactivity Disorder (MTA Study). Continuation Aim 1 is to track the persistence of intervention-related effects as the MTA sample matures into mid-adolescence, including subsequent mental-health and school-related service utilization patterns as a function of MTA treatment experience (treatment assignment) and outcome (degree of treatment success at 14 mo.). Aim 2 is to test specific hypotheses about predictors, mediators, and moderators of long-term outcome among children with ADHD (e.g., comorbidity; family functioning; cognitive skills; peer relations) that may influence adolescent functioning (either independent of or through initial treatment assignment and/or 14-month treatment outcomes); and to compare how these predictors, mediators, and moderators are similar or dissimilar within the normal comparison group. Aim 3 is to track the patterns of risk and protective factors (including their mediation or moderation by initial treatment assignment and/or outcome) involved in early and subsequent stages of developing substance-related disorders and antisocial behavior. Aim 4 is to examine the effect of initial treatment assignment and degree of treatment success on later academic performance, achievement, school conduct, tendency to drop out, and other adverse school outcomes.

In the original MTA design, patients were randomly assigned to 1 of 4 treatment conditions: (1) medication only; (2) psychosocial only; (3) combined (medication and psychosocial); or (4) Assessment-and-Referral condition. All but the latter were treated intensively for 14 months, with assessments for all subjects at baseline, 3, 9, 14, and 24 months. The original MTA design thus provides short-term (10 months post-treatment) follow-up at 24 months. This continuation extends the follow-up to assessments at 36, 60, and 84 months after treatment.

A child may be eligible for this study if he/she:

Is 7 - 9 years old, and has Attention Deficit Hyperactivity Disorder (ADHD).


Description:

This trial is a continuation of the Multimodal Treatment Study of Children with Attention Deficit Hyperactivity Disorder (MTA Study). Continuation Aim 1 is to track the persistence of intervention-related effects as the MTA sample matures into mid-adolescence, including subsequent mental-health and school-related service utilization patterns as a function of MTA treatment experience (treatment assignment) and outcome (degree of treatment success at 14 mo.). Aim 2 is to test specific hypotheses about predictors, mediators, and moderators of long-term outcome among children with ADHD (e.g., comorbidity; family functioning; cognitive skills; peer relations) that may influence adolescent functioning (either independent of or through initial treatment assignment and/or 14-month treatment outcomes); and to compare how these predictors, mediators, and moderators are similar or dissimilar within the normal comparison group. Aim 3 is to track the patterns of risk and protective factors (including their mediation or moderation by initial treatment assignment and/or outcome) involved in early and subsequent stages of developing substance-related disorders and antisocial behavior. Aim 4 is to examine the effect of initial treatment assignment and degree of treatment success on later academic performance, achievement, school conduct, tendency to drop out, and other adverse school outcomes.

In the original MTA design, patients were randomly assigned to 1 of 4 treatment conditions: (1) medication only; (2) psychosocial only; (3) combined (medication and psychosocial); or (4) Assessment-and-Referral condition. All but the latter were treated intensively for 14 months, with assessments for all subjects at baseline, 3, 9, 14, and 24 months. The original MTA design thus provides short-term (10 months post-treatment) follow-up at 24 months. This continuation extends the follow-up to assessments at 36, 60, and 84 months after treatment.


Recruitment information / eligibility

Status Completed
Enrollment 0
Est. completion date November 1999
Est. primary completion date
Accepts healthy volunteers
Gender Both
Age group 7 Years to 9 Years
Eligibility Inclusion Criteria:

Patients must have:

Rigorously diagnosed Attention Deficit Hyperactivity Disorder (ADHD).

Study Design

Allocation: Randomized, Primary Purpose: Treatment


Related Conditions & MeSH terms


Intervention

Behavioral:
Psychosocial treatment

Drug:
Anti-ADHD medication

Behavioral:
Assessment-and-Referral


Locations

Country Name City State
n/a

Sponsors (2)

Lead Sponsor Collaborator
New York University School of Medicine National Institute of Mental Health (NIMH)

References & Publications (80)

A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD. Arch Gen Psychiatry. 1999 Dec;56(12):1073-86. — View Citation

Abikoff H, Arnold LE, Newcorn JH, Elliott GR, Hechtman L, Severe JB, Wigal T, Shapiro C, Cantwell DP, Conners CK, Greenhill LL, Hinshaw SP, Hoza B, Jensen PS, Kraemer HC, March JS, Pelham WE, Swanson JM, Vitiello B, Wells KC. Emergency/Adjunct services an — View Citation

Abikoff H. Tailored psychosocial treatments for ADHD: the search for a good fit. J Clin Child Psychol. 2001 Mar;30(1):122-5. — View Citation

Arnold LE, Abikoff HB, Cantwell DP, Conners CK, Elliott G, Greenhill LL, Hechtman L, Hinshaw SP, Hoza B, Jensen PS, Kraemer HC, March JS, Newcorn JH, Pelham WE, Richters JE, Schiller E, Severe JB, Swanson JM, Vereen D, Wells KC. National Institute of Ment — View Citation

Arnold LE, Chuang S, Davies M, Abikoff HB, Conners CK, Elliott GR, Greenhill LL, Hechtman L, Hinshaw SP, Hoza B, Jensen PS, Kraemer HC, Langworthy-Lam KS, March JS, Newcorn JH, Pelham WE, Severe JB, Swanson JM, Vitiello B, Wells KC, Wigal T. Nine months o — View Citation

Arnold LE, Elliot M, Sachs L, Bird H, Kraemer HC, Wells KC, Abikoff HB, Comarda A, Conners CK, Elliott GR, Greenhill LL, Hechtman L, Hindshaw SP, Hoza B, Jensen PS, March JS, Newcorn JH, Pelham WE, Severe JB, Swanson JM, Vitiello B, Wigal T. Effects of ethnicity on treatment attendance, stimulant response/dose, and 14-month outcome in ADHD. J Consult Clin Psychol. 2003 Aug;71(4):713-27. — View Citation

Arnold, L. E., Abikoff, H. B., Cantwell, D. P., Conners, C. K., Elliott, G. R., Greenhill, L. L.,Hechtman, L., Hinshaw, S.P., Hoza B., Jensen, P.S., Kraemer, H.C, March, J.S., Newcorn, J.H., Pelham, W.E., Richters, J.E., Schiller, E., Severe, J.B., Swanso

Arnold, L. E., Elliott, M., Lindsay, R. L., Molina, B., Cornelius, M. D., Vitiello, B., . . . Wells, K. (2005). Gestational and postnatal tobacco smoke exposure as predictor of ADHD, comorbid ODD/CD, and treatment response in the MTA. Clinical Neuroscienc

Conners CK, Epstein JN, March JS, Angold A, Wells KC, Klaric J, Swanson JM, Arnold LE, Abikoff HB, Elliott GR, Greenhill LL, Hechtman L, Hinshaw SP, Hoza B, Jensen PS, Kraemer HC, Newcorn JH, Pelham WE, Severe JB, Vitiello B, Wigal T. Multimodal treatment — View Citation

Epstein JN, Conners CK, Erhardt D, Arnold LE, Hechtman L, Hinshaw SP, Hoza B, Newcorn JH, Swanson JM, Vitiello B. Familial aggregation of ADHD characteristics. J Abnorm Child Psychol. 2000 Dec;28(6):585-94. — View Citation

Epstein JN, Conners CK, Hervey AS, Tonev ST, Arnold LE, Abikoff HB, Elliott G, Greenhill LL, Hechtman L, Hoagwood K, Hinshaw SP, Hoza B, Jensen PS, March JS, Newcorn JH, Pelham WE, Severe JB, Swanson JM, Wells K, Vitiello B, Wigal T; MTA Cooperative Study — View Citation

Galanter CA, Carlson GA, Jensen PS, Greenhill LL, Davies M, Li W, Chuang SZ, Elliott GR, Arnold LE, March JS, Hechtman L, Pelham WE, Swanson JM. Response to methylphenidate in children with attention deficit hyperactivity disorder and manic symptoms in th — View Citation

Galanter, C. A., Pagar, D. L., Davies, M., Li, W., Carlson, G. A., Abikoff, H. B., . . . Jensen, P. S. (2005). ADHD and manic symptoms: Diagnostic and treatment implications. Clinical Neuroscience Research, 5(5-6), 283-294.

Gerdes AC, Hoza B, Arnold LE, Hinshaw SP, Wells KC, Hechtman L, Greenhill LL, Swanson JM, Pelham WE, Wigal T. Child and parent predictors of perceptions of parent--child relationship quality. J Atten Disord. 2007 Jul;11(1):37-48. — View Citation

Gerdes AC, Hoza B, Arnold LE, Pelham WE, Swanson JM, Wigal T, Jensen PS. Maternal depressive symptomatology and parenting behavior: exploration of possible mediators. J Abnorm Child Psychol. 2007 Oct;35(5):705-14. Epub 2007 Aug 3. — View Citation

Greenfield B, Hechtman L, Stehli A, Wigal T. Sexual maturation among youth with ADHD and the impact of stimulant medication. Eur Child Adolesc Psychiatry. 2014 Sep;23(9):835-9. doi: 10.1007/s00787-014-0521-3. Epub 2014 Feb 2. — View Citation

Greenhill LL, Abikoff HB, Arnold LE, Cantwell DP, Conners CK, Elliott G, Hechtman L, Hinshaw SP, Hoza B, Jensen PS, March JS, Newcorn J, Pelham WE, Severe JB, Swanson JM, Vitiello B, Wells K. Medication treatment strategies in the MTA Study: relevance to — View Citation

Greenhill LL, Swanson JM, Vitiello B, Davies M, Clevenger W, Wu M, Arnold LE, Abikoff HB, Bukstein OG, Conners CK, Elliott GR, Hechtman L, Hinshaw SP, Hoza B, Jensen PS, Kraemer HC, March JS, Newcorn JH, Severe JB, Wells K, Wigal T. Impairment and deportm — View Citation

Hechtman, L., Etcovitch, J., Platt, R., Arnold, L. E., Abikoff, H. B., Newcorn, J. H., . . . Wigal, T. (2005). Does multimodal treatment of ADHD decrease other diagnoses? Clinical Neuroscience Research, 5(5-6), 273-282.

Hervey AS, Epstein JN, Curry JF, Tonev S, Eugene Arnold L, Keith Conners C, Hinshaw SP, Swanson JM, Hechtman L. Reaction time distribution analysis of neuropsychological performance in an ADHD sample. Child Neuropsychol. 2006 Apr;12(2):125-40. — View Citation

Hinshaw SP, Owens EB, Wells KC, Kraemer HC, Abikoff HB, Arnold LE, Conners CK, Elliott G, Greenhill LL, Hechtman L, Hoza B, Jensen PS, March JS, Newcorn JH, Pelham WE, Swanson JM, Vitiello B, Wigal T. Family processes and treatment outcome in the MTA: neg — View Citation

Hinshaw SP. Moderators and mediators of treatment outcome for youth with ADHD: understanding for whom and how interventions work. Ambul Pediatr. 2007 Jan-Feb;7(1 Suppl):91-100. Review. — View Citation

Hinshaw SP. Moderators and mediators of treatment outcome for youth with ADHD: understanding for whom and how interventions work. J Pediatr Psychol. 2007 Jul;32(6):664-75. Epub 2007 Jan 29. Review. — View Citation

Hinshaw, S. P., March, J. S., Abikoff, H., Arnold, L. E., Cantwell, D. P., Conners, C. K., . . . Wigal, T. (1997). Comprehensive assessment of childhood attention-deficit hyperactivity disorder in the context of a multisite, multimodal clinical trial. Jou

Hoza B, Gerdes AC, Hinshaw SP, Arnold LE, Pelham WE Jr, Molina BS, Abikoff HB, Epstein JN, Greenhill LL, Hechtman L, Odbert C, Swanson JM, Wigal T. Self-perceptions of competence in children with ADHD and comparison children. J Consult Clin Psychol. 2004 Jun;72(3):382-91. — View Citation

Hoza B, Gerdes AC, Mrug S, Hinshaw SP, Bukowski WM, Gold JA, Arnold LE, Abikoff HB, Conners CK, Elliott GR, Greenhill LL, Hechtman L, Jensen PS, Kraemer HC, March JS, Newcorn JH, Severe JB, Swanson JM, Vitiello B, Wells KC, Wigal T. Peer-assessed outcomes — View Citation

Hoza B, Kaiser NM, Hurt E. Multimodal treatments for childhood attention-deficit/hyperactivity disorder: interpreting outcomes in the context of study designs. Clin Child Fam Psychol Rev. 2007 Dec;10(4):318-34. Review. — View Citation

Hoza B, McQuade JD, Murray-Close D, Shoulberg E, Molina BS, Arnold LE, Swanson J, Hechtman L. Does childhood positive self-perceptual bias mediate adolescent risky behavior in youth from the MTA study? J Consult Clin Psychol. 2013 Oct;81(5):846-58. doi: 1 — View Citation

Hoza B, Owens JS, Pelham WE, Swanson JM, Conners CK, Hinshaw SP, Arnold LE, Kraemer HC. Parent cognitions as predictors of child treatment response in attention-deficit/hyperactivity disorder. J Abnorm Child Psychol. 2000 Dec;28(6):569-83. — View Citation

Hoza B. Psychosocial treatment issues in the MTA: a reply to Greene and Ablon. J Clin Child Psychol. 2001 Mar;30(1):126-30. — View Citation

Jensen PS, Arnold LE, Swanson JM, Vitiello B, Abikoff HB, Greenhill LL, Hechtman L, Hinshaw SP, Pelham WE, Wells KC, Conners CK, Elliott GR, Epstein JN, Hoza B, March JS, Molina BS, Newcorn JH, Severe JB, Wigal T, Gibbons RD, Hur K. 3-year follow-up of th — View Citation

Jensen PS, Garcia JA, Glied S, Crowe M, Foster M, Schlander M, Hinshaw S, Vitiello B, Arnold LE, Elliott G, Hechtman L, Newcorn JH, Pelham WE, Swanson J, Wells K. Cost-effectiveness of ADHD treatments: findings from the multimodal treatment study of child — View Citation

Jensen PS, Hinshaw SP, Kraemer HC, Lenora N, Newcorn JH, Abikoff HB, March JS, Arnold LE, Cantwell DP, Conners CK, Elliott GR, Greenhill LL, Hechtman L, Hoza B, Pelham WE, Severe JB, Swanson JM, Wells KC, Wigal T, Vitiello B. ADHD comorbidity findings fro — View Citation

Jensen PS, Hinshaw SP, Swanson JM, Greenhill LL, Conners CK, Arnold LE, Abikoff HB, Elliott G, Hechtman L, Hoza B, March JS, Newcorn JH, Severe JB, Vitiello B, Wells K, Wigal T. Findings from the NIMH Multimodal Treatment Study of ADHD (MTA): implications and applications for primary care providers. J Dev Behav Pediatr. 2001 Feb;22(1):60-73. — View Citation

Jensen PS. Fact versus fancy concerning the multimodal treatment study for attention-deficit hyperactivity disorder. Can J Psychiatry. 1999 Dec;44(10):975-80. Review. — View Citation

Johnston C, Murray C, Hinshaw SP, William EP Jr, Hoza B. Responsiveness in interactions of mothers and sons with ADHD: relations to maternal and child characteristics. J Abnorm Child Psychol. 2002 Feb;30(1):77-88. — View Citation

Jones HA, Epstein JN, Hinshaw SP, Owens EB, Chi TC, Arnold LE, Hoza B, Wells KC. Ethnicity as a moderator of treatment effects on parent--child interaction for children with ADHD. J Atten Disord. 2010 May;13(6):592-600. doi: 10.1177/1087054709332158. Epub 2009 Jun 16. — View Citation

Kolko DJ, Bukstein OG, Barron J. Methylphenidate and behavior modification in children with ADHD and comorbid ODD or CD: main and incremental effects across settings. J Am Acad Child Adolesc Psychiatry. 1999 May;38(5):578-86. — View Citation

Laforett DR, Murray DW, Kollins SH. Psychosocial treatments for preschool-aged children with Attention-Deficit Hyperactivity Disorder. Dev Disabil Res Rev. 2008;14(4):300-10. doi: 10.1002/ddrr.36. Review. — View Citation

Langberg JM, Arnold LE, Flowers AM, Epstein JN, Altaye M, Hinshaw SP, Swanson JM, Kotkin R, Simpson S, Molina BS, Jensen PS, Abikoff H, Pelham WE Jr, Vitiello B, Wells KC, Hechtman L. Parent-reported homework problems in the MTA study: evidence for sustai — View Citation

Langberg JM, Epstein JN, Altaye M, Molina BS, Arnold LE, Vitiello B. The transition to middle school is associated with changes in the developmental trajectory of ADHD symptomatology in young adolescents with ADHD. J Clin Child Adolesc Psychol. 2008 Jul;37(3):651-63. doi: 10.1080/15374410802148095. — View Citation

Langberg JM, Epstein JN, Simon JO, Loren RE, Arnold LE, Hechtman L, Hinshaw SP, Hoza B, Jensen PS, Pelham WE, Swanson JM, Wigal T. Parental Agreement on ADHD Symptom-Specific and Broadband Externalizing Ratings of Child Behavior. J Emot Behav Disord. 2010 Mar;18(1):41-50. — View Citation

March JS, Swanson JM, Arnold LE, Hoza B, Conners CK, Hinshaw SP, Hechtman L, Kraemer HC, Greenhill LL, Abikoff HB, Elliott LG, Jensen PS, Newcorn JH, Vitiello B, Severe J, Wells KC, Pelham WE. Anxiety as a predictor and outcome variable in the multimodal — View Citation

Marcus, S. M., & Gibbons, R. D. (2001). Estimating the efficacy of receiving treatment in randomized clinical trials with noncompliance. Health Services and Outcomes Research Methodology, 2(3-4), 247-258.

Mikami AY, Hinshaw SP, Arnold LE, Hoza B, Hechtman L, Newcorn JH, Abikoff HB. Bulimia nervosa symptoms in the multimodal treatment study of children with ADHD. Int J Eat Disord. 2010 Apr;43(3):248-59. doi: 10.1002/eat.20692. — View Citation

Moderators and mediators of treatment response for children with attention-deficit/hyperactivity disorder: the Multimodal Treatment Study of children with Attention-deficit/hyperactivity disorder. Arch Gen Psychiatry. 1999 Dec;56(12):1088-96. — View Citation

Molina BS, Flory K, Hinshaw SP, Greiner AR, Arnold LE, Swanson JM, Hechtman L, Jensen PS, Vitiello B, Hoza B, Pelham WE, Elliott GR, Wells KC, Abikoff HB, Gibbons RD, Marcus S, Conners CK, Epstein JN, Greenhill LL, March JS, Newcorn JH, Severe JB, Wigal T — View Citation

Molina BS, Hinshaw SP, Eugene Arnold L, Swanson JM, Pelham WE, Hechtman L, Hoza B, Epstein JN, Wigal T, Abikoff HB, Greenhill LL, Jensen PS, Wells KC, Vitiello B, Gibbons RD, Howard A, Houck PR, Hur K, Lu B, Marcus S; MTA Cooperative Group. Adolescent sub — View Citation

Molina BS, Hinshaw SP, Swanson JM, Arnold LE, Vitiello B, Jensen PS, Epstein JN, Hoza B, Hechtman L, Abikoff HB, Elliott GR, Greenhill LL, Newcorn JH, Wells KC, Wigal T, Gibbons RD, Hur K, Houck PR; MTA Cooperative Group. The MTA at 8 years: prospective f — View Citation

Mrug S, Hoza B, Gerdes AC, Hinshaw S, Arnold LE, Hechtman L, Pelham WE. Discriminating between children with ADHD and classmates using peer variables. J Atten Disord. 2009 Jan;12(4):372-80. doi: 10.1177/1087054708314602. Epub 2008 Apr 3. — View Citation

Mrug S, Molina BS, Hoza B, Gerdes AC, Hinshaw SP, Hechtman L, Arnold LE. Peer rejection and friendships in children with Attention-Deficit/Hyperactivity Disorder: contributions to long-term outcomes. J Abnorm Child Psychol. 2012 Aug;40(6):1013-26. doi: 10.1007/s10802-012-9610-2. — View Citation

MTA Cooperative Group. National Institute of Mental Health Multimodal Treatment Study of ADHD follow-up: 24-month outcomes of treatment strategies for attention-deficit/hyperactivity disorder. Pediatrics. 2004 Apr;113(4):754-61. — View Citation

MTA Cooperative Group. National Institute of Mental Health Multimodal Treatment Study of ADHD follow-up: changes in effectiveness and growth after the end of treatment. Pediatrics. 2004 Apr;113(4):762-9. — View Citation

Murray DW. Treatment of preschoolers with attention-deficit/hyperactivity disorder. Curr Psychiatry Rep. 2010 Oct;12(5):374-81. doi: 10.1007/s11920-010-0142-6. Review. — View Citation

Murray-Close D, Hoza B, Hinshaw SP, Arnold LE, Swanson J, Jensen PS, Hechtman L, Wells K. Developmental processes in peer problems of children with attention-deficit/hyperactivity disorder in the Multimodal Treatment Study of Children With ADHD: developme — View Citation

Newcorn JH, Halperin JM, Jensen PS, Abikoff HB, Arnold LE, Cantwell DP, Conners CK, Elliott GR, Epstein JN, Greenhill LL, Hechtman L, Hinshaw SP, Hoza B, Kraemer HC, Pelham WE, Severe JB, Swanson JM, Wells KC, Wigal T, Vitiello B. Symptom profiles in children with ADHD: effects of comorbidity and gender. J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):137-46. — View Citation

Newcorn, J. H. (2004). Comorbidity of ADHD and disruptive behavior disorders: Prevalence, impact, and management options. Drug Benefit Trends, 16(8), 431-436.

Owens EB, Hinshaw SP, Kraemer HC, Arnold LE, Abikoff HB, Cantwell DP, Conners CK, Elliott G, Greenhill LL, Hechtman L, Hoza B, Jensen PS, March JS, Newcorn JH, Pelham WE, Severe JB, Swanson JM, Vitiello B, Wells KC, Wigal T. Which treatment for whom for A — View Citation

Owens EB, Hinshaw SP. Perinatal problems and psychiatric comorbidity among children with ADHD. J Clin Child Adolesc Psychol. 2013;42(6):762-8. doi: 10.1080/15374416.2013.785359. Epub 2013 Apr 14. — View Citation

Pappadopulos E, Jensen PS, Chait AR, Arnold LE, Swanson JM, Greenhill LL, Hechtman L, Chuang S, Wells KC, Pelham W, Cooper T, Elliott G, Newcorn JH. Medication adherence in the MTA: saliva methylphenidate samples versus parent report and mediating effect — View Citation

Paule MG, Rowland AS, Ferguson SA, Chelonis JJ, Tannock R, Swanson JM, Castellanos FX. Attention deficit/hyperactivity disorder: characteristics, interventions and models. Neurotoxicol Teratol. 2000 Sep-Oct;22(5):631-51. Review. — View Citation

Pelham WE Jr. The NIMH multimodal treatment study for attention-deficit hyperactivity disorder: just say yes to drugs alone? Can J Psychiatry. 1999 Dec;44(10):981-90. Review. — View Citation

Pelham WE, Gnagy EM, Greiner AR, Hoza B, Hinshaw SP, Swanson JM, Simpson S, Shapiro C, Bukstein O, Baron-Myak C, McBurnett K. Behavioral versus behavioral and pharmacological treatment in ADHD children attending a summer treatment program. J Abnorm Child Psychol. 2000 Dec;28(6):507-25. — View Citation

Rabiner DL, Murray DW, Rosen L, Hardy K, Skinner A, Underwood M. Instability in teacher ratings of children's inattentive symptoms: implications for the assessment of ADHD. J Dev Behav Pediatr. 2010 Apr;31(3):175-80. doi: 10.1097/DBP.0b013e3181d5a2d8. — View Citation

Richters JE, Arnold LE, Jensen PS, Abikoff H, Conners CK, Greenhill LL, Hechtman L, Hinshaw SP, Pelham WE, Swanson JM. NIMH collaborative multisite multimodal treatment study of children with ADHD: I. Background and rationale. J Am Acad Child Adolesc Psyc — View Citation

Santosh, P. J., Taylor, E., Swanson, J., Wigal, T., Chuang, S., Davies, M., . . . Posner, M. (2005). Refining the diagnoses of inattention and overactivity syndromes: A reanalysis of the multimodal treatment study of attention deficit hyperactivity disorder (ADHD) based on ICD-10 criteria for hyperkinetic disorder. Clinical Neuroscience Research, 5(5-6), 307-314.

Shaw M, Hodgkins P, Caci H, Young S, Kahle J, Woods AG, Arnold LE. A systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: effects of treatment and non-treatment. BMC Med. 2012 Sep 4;10:99. doi: 10.1186/1741-7015-10-99. Review. — View Citation

Stevens J, Kelleher K, Greenhouse J, Chen G, Xiang H, Kaizar E, Jensen PS, Arnold LE. Empirical evaluation of the generalizability of the sample from the multimodal treatment study for ADHD. Adm Policy Ment Health. 2007 May;34(3):221-32. Epub 2006 Oct 20. — View Citation

Swanson J, Arnold LE, Kraemer H, Hechtman L, Molina B, Hinshaw S, Vitiello B, Jensen P, Steinhoff K, Lerner M, Greenhill L, Abikoff H, Wells K, Epstein J, Elliott G, Newcorn J, Hoza B, Wigal T; MTA Cooperative Group. Evidence, interpretation, and qualific — View Citation

Swanson J, Arnold LE, Kraemer H, Hechtman L, Molina B, Hinshaw S, Vitiello B, Jensen P, Steinhoff K, Lerner M, Greenhill L, Abikoff H, Wells K, Epstein J, Elliott G, Newcorn J, Hoza B, Wigal T; MTA Cooperative Group. Evidence, interpretation, and qualific — View Citation

Swanson JM, Arnold LE, Vitiello B, Abikoff HB, Wells KC, Pelham WE, March JS, Hinshaw SP, Hoza B, Epstein JN, Elliott GR, Greenhill LL, Hechtman L, Jensen PS, Kraemer HC, Kotkin R, Molina B, Newcorn JH, Owens EB, Severe J, Hoagwood K, Simpson S, Wigal T, — View Citation

Swanson JM, Elliott GR, Greenhill LL, Wigal T, Arnold LE, Vitiello B, Hechtman L, Epstein JN, Pelham WE, Abikoff HB, Newcorn JH, Molina BS, Hinshaw SP, Wells KC, Hoza B, Jensen PS, Gibbons RD, Hur K, Stehli A, Davies M, March JS, Conners CK, Caron M, Volk — View Citation

Swanson JM, Hinshaw SP, Arnold LE, Gibbons RD, Marcus S, Hur K, Jensen PS, Vitiello B, Abikoff HB, Greenhill LL, Hechtman L, Pelham WE, Wells KC, Conners CK, March JS, Elliott GR, Epstein JN, Hoagwood K, Hoza B, Molina BS, Newcorn JH, Severe JB, Wigal T. — View Citation

Swanson JM, Kraemer HC, Hinshaw SP, Arnold LE, Conners CK, Abikoff HB, Clevenger W, Davies M, Elliott GR, Greenhill LL, Hechtman L, Hoza B, Jensen PS, March JS, Newcorn JH, Owens EB, Pelham WE, Schiller E, Severe JB, Simpson S, Vitiello B, Wells K, Wigal — View Citation

Vaughn AJ, Epstein JN, Rausch J, Altaye M, Langberg J, Newcorn JH, Hinshaw SP, Hechtman L, Arnold LE, Swanson JM, Wigal T. Relation between outcomes on a continuous performance test and ADHD symptoms over time. J Abnorm Child Psychol. 2011 Aug;39(6):853-64. doi: 10.1007/s10802-011-9501-y. — View Citation

Vitiello B, Elliott GR, Swanson JM, Arnold LE, Hechtman L, Abikoff H, Molina BS, Wells K, Wigal T, Jensen PS, Greenhill LL, Kaltman JR, Severe JB, Odbert C, Hur K, Gibbons R. Blood pressure and heart rate over 10 years in the multimodal treatment study of children with ADHD. Am J Psychiatry. 2012 Feb;169(2):167-77. doi: 10.1176/appi.ajp.2011.10111705. — View Citation

Vitiello B, Severe JB, Greenhill LL, Arnold LE, Abikoff HB, Bukstein OG, Elliott GR, Hechtman L, Jensen PS, Hinshaw SP, March JS, Newcorn JH, Swanson JM, Cantwell DP. Methylphenidate dosage for children with ADHD over time under controlled conditions: les — View Citation

Wells KC, Chi TC, Hinshaw SP, Epstein JN, Pfiffner L, Nebel-Schwalm M, Owens EB, Arnold LE, Abikoff HB, Conners CK, Elliott GR, Greenhill LL, Hechtman L, Hoza B, Jensen PS, March J, Newcorn JH, Pelham WE, Severe JB, Swanson J, Vitiello B, Wigal T. Treatme — View Citation

Wells KC, Pelham WE, Kotkin RA, Hoza B, Abikoff HB, Abramowitz A, Arnold LE, Cantwell DP, Conners CK, Del Carmen R, Elliott G, Greenhill LL, Hechtman L, Hibbs E, Hinshaw SP, Jensen PS, March JS, Swanson JM, Schiller E. Psychosocial treatment strategies in — View Citation

Wells KC. Comprehensive versus matched psychosocial treatment in the MTA study: conceptual and empirical issues. J Clin Child Psychol. 2001 Mar;30(1):131-5. — View Citation

* Note: There are 80 references in allClick here to view all references

See also
  Status Clinical Trial Phase
Recruiting NCT05054738 - CRP and S&A for Inpatient Veterans N/A
Recruiting NCT04157062 - An Open-Label Trial of Repetitive Transcranial Magnetic Stimulation for Opioid Use Disorder N/A
Completed NCT02233738 - Group Motivational Interviewing (GMI) For Homeless Veterans In VA Services N/A
Enrolling by invitation NCT06084221 - Fatal Overdose Review Teams - Research to Enhance Surveillance Systems N/A
Completed NCT02907944 - Working With HIV Clinics to Adopt Addiction Treatments Using Implementation Facilitation N/A
Completed NCT02829970 - Helping College Students With ADHD Lead Healthier Lifestyles N/A
Completed NCT02570360 - Exercise and Treatment-as-usual in Substance Use Treatment Outcomes N/A
Completed NCT02715557 - Arise: An Online Relapse Prevention Tool for Adolescent Substance Abusers N/A
Completed NCT02388243 - The Computer-based Drug and Alcohol Training Assessment in Kenya N/A
Completed NCT02125539 - Field Trial of a Relapse Prevention Program for Adolescents Receiving Substance Use Treatment Phase 2
Completed NCT02945371 - Tailored Inhibitory Control Training to Reverse EA-linked Deficits in Mid-life N/A
Completed NCT01633138 - Performance-based Reinforcement to Enhance Cognitive Remediation Therapy N/A
Completed NCT02218970 - The Effect of Muscular Strength Training in Patients With Drug Addiction N/A
Completed NCT01591239 - Home-Based Program to Help Parents of Drug Abusing Adolescents N/A
Active, not recruiting NCT01539525 - Screening to Augment Referral to Treatment- Project START Phase 2
Withdrawn NCT01224002 - A Comparative Feasibility Study to Assess the Prevalence and Severity of Dental Caries in Incarcerated People Who Abuse Methamphetamine N/A
Withdrawn NCT00891631 - Primary Care iSBIRT to Reduce Serious Teen Health Risks Phase 1/Phase 2
Completed NCT00970372 - Dual-Diagnosis and Compulsory Treatment N/A
Completed NCT01365247 - Concurrent Treatment for Substance Dependent Individuals With Post-Traumatic Stress Disorder (PTSD) N/A
Completed NCT00419029 - Motivational Interviewing to Engage Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) Veterans in Mental Health Treatment N/A