Substance-Related Disorders Clinical Trial
Official title:
Atomoxetine in Adolescents With Attention Deficit Hyperactivity Disorder (ADHD) and Substance Use Disorder (SUD)
Adolescents with attention deficit hyperactivity disorder (ADHD) often develop substance use disorders (SUD). The purpose of this study is to evaluate the effectiveness of atomoxetine in treating adolescents dually diagnosed with ADHD and SUD.
High rates of ADHD have been reported in adolescents with SUD. In addition, untreated ADHD
is a risk factor for developing SUD. Atomoxetine is a norepinephrine reuptake inhibitor, and
is currently used to treat adolescents with ADHD. The purpose of this trial is to evaluate
the efficacy of atomoxetine in treating adolescents dually diagnosed with ADHD and SUD.
This study will last up to 18 weeks. Participants will receive six treatments of
manual-driven, cognitive behavioral therapy for substance abuse over at 6 or earlier weeks.
Participants and their parents will partake in therapy sessions. Subjects who have completed
at least 2 weeks of CBT will be eligible to enter the controlled trial, at which point
participants will be randomly assigned to receive either atomoxetine or placebo, which they
will take once daily for 12 weeks. At the Week 12 study visit, participants will be assessed
for symptoms of ADHD and SUD.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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