Efficacy of Cognitive Bias Modification in Residential Treatment for Addiction

Substance Dependence Clinical Trial

Official title:

Efficacy of Cognitive Bias Modification in Residential Treatment for Addiction

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03000699
• Other study ID #: 077/2016
• Status: Completed
• Phase: N/A
• Start date: March 1, 2017
• Est. completion date: December 31, 2018

Study information

• Verified date: January 2019
• Source: Centre for Addiction and Mental Health
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine whether computer bias modification for interpretation bias (CBM-I) is effective in the reduction of suicidal ideation in substance use disorders.

Description:

Eighty-eight adult inpatients completing residential treatment in the Addictions Services at the Centre for Addiction and Mental Health (CAMH) will be randomized to receive CBM-I daily for one week, adjunct to the residential psychosocial treatment or to an assessment-only control condition. Participants will complete clinical measures consisting of interviews and questionnaires measuring suicidal ideation, hopelessness, depression, negative affect, and interpretation biases before, during and after treatment.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 88
• Est. completion date: December 31, 2018
• Est. primary completion date: October 1, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Exhibit moderate suicide risk or greater

• Be enrolled in the Addictions Services inpatient program

• Fluent in reading English

• Capacity to give informed consent

Exclusion Criteria:

• A lifetime diagnosis of a psychotic or bipolar disorder

• Significant neurological disorder or psychical illness likely to interfere with participation

• Psychotropic medication changes within the past two weeks

Related Conditions & MeSH terms

• Substance Dependence
• Substance-Related Disorders

Intervention

Behavioral:
• Cognitive Bias Modification
Training paragraphs describe scenarios designed to be ambiguous at the outset and to resolve in a positive direction, with the intention of establishing a learning contingency between the ambiguity at the beginning of the scenario and the positive resolution that becomes clear towards the end of the statement.

Locations

Country	Name	City	State
Canada	Centre for Addiction and Mental Health	Toronto	Ontario

Sponsors (2)

Lead Sponsor	Collaborator
Centre for Addiction and Mental Health	American Foundation for Suicide Prevention

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Columbia-Suicide Severity Rating Scale, Screen Version (C-SSRS)	This scale quantifies the severity of suicidal ideation and behaviour.	Seven days
Secondary	Beck Hopelessness Scale (BHS)	This questionnaire assesses thoughts and emotions associated with the future.	Seven days
Secondary	Beck Depression Inventory II (BDI-II)	This questionnaire assesses severity of depressive symptoms and cognitions.	Seven days
Secondary	Positive and Negative Affect Schedule (PANAS)	This questionnaire assesses current positive and negative mood	Seven days
Secondary	Scrambled Sentences Tests	This computer test will be used as an implicit measure of negative interpretation bias.	Seven days

External Links

•   Information about research at the Centre for Addiction and Mental Health