Subfertility, Female Clinical Trial
Official title:
Effect of Sildenafil Citrate Compared to Estrogen as Adjuvant Therapy on Improvement of Endometrial Thickness and Treatment of Unexplained Infertility
. This study aimed to determine and compare the effect of vaginal sildenafil citrate and estradiol valerate on endometrial thickness, blood flow and pregnancy rates in infertile women.
The study is a randomized controlled trial that was carried on 148 infertile women with unexplained infertility. Patients were divided into 3 groups. Group 1 included 48 patients who received oral estradiol valerate (Cyclo-Progynova 2mg, from day 8th till triggering of ovulation), another 50 patients in group 2 received oral Sildenafil (Respatio 20mg/12hr film coated tablets for 5 days starting from last day of menstruation till ovulation), while group 3 was the control one who included 50 patients were given ovulation induction with CC 50mg/12hr from 2nd to 7th day of cycle. Every patient underwent a transvaginal ultrasound to determine ovulation, number of follicles, and pregnancy rates. Miscarriage, ectopic pregnancy, and multiple pregnancies were tracked for 3 months, as were any adverse consequences. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06051201 -
Innovation for Small-scale Experiments: ReceptIVFity Test
|
N/A | |
| Recruiting |
NCT03881904 -
OCP Pretreatment in PCOS Patients Undergoing ICSI Using Antagonist Protocol
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05677269 -
The (Cost-)Effectiveness of Surgical Excision of Colorectal Endometriosis Compared to ART Treatment Trajectory
|
||
| Not yet recruiting |
NCT02940535 -
Low Dose GnRHa Early Luteal Phase Down Regulation Versus GnRHa Ultra-short Protocol for Poor Ovarian Response
|
N/A | |
| Recruiting |
NCT05211583 -
Serial Progesterone Level Measurements During the Menstrual Cycle in Subfertile Women
|
||
| Completed |
NCT05137964 -
A Cross Sectional Evaluation of Vitamin D Status and Ovarian Reserve Markers
|