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Thyroid Screening Protocol During Pregnancy: a Multi-center Prospective Controlled Study

Subclinical Hypothyroidism Clinical Trial

Official title:
Randomized Thyroid Screening Protocol During Pregnancy: a Multi-center Prospective Controlled Study

Clinical Trial Summary

Estimate the proper thyroid screening method during pregnancy. Evaluate if maternal subclinical hypothyroidism treatment during pregnancy result in improved pregnancy outcome and cognitive function in the children.

Clinical Trial Description

The investigators conducted a single-blinded trial in which pregnant women at a gestation of less than 12 weeks, usually 6 to 8 weeks, provided blood samples for measurement of thyrotropin, free thyroxine(FT4) and thyroid peroxidase antibody (TPOAb). Women were assigned to a screening group in PUMCH (in which measurements were obtained immediately) or a control group in HMCHH (in which serum was stored and measurements were obtained shortly after delivery). Each group enrolled 1000 pregnant women separately. Women with positive findings in the screening group were given individualized levothyroxine treatment and regular follow-up. Compare the pregnancy outcomes, IQ at 2-3 years of age in children of women with subclinical hypothyroidism between two groups. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01838031
Study type Interventional
Source Peking Union Medical College Hospital
Contact
Status Completed
Phase N/A
Start date September 2011
Completion date September 2013
View Details
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