Subarachnoid Hemorrhage Clinical Trial
— SEASOfficial title:
Serial Echocardiography After Subarachnoid Hemorrhage (S.E.A.S.)
There is increasing interest in myocardial abnormalities following central nervous system
events, such as subarachnoid hemorrhage (SAH). These cardiac abnormalities include ECG
changes, decreased cardiac output, decreased blood pressure, specific cardiac enzyme
elevations, and segmental wall motion abnormalities (SWMA). Interestingly, wall motion
abnormalities and ECG changes have shown to be reversible, and therefore the dysfunction has
been described as neurogenic myocardial stunning.
The pathophysiology of cardiac dysfunction following SAH has not yet been fully elucidated.
Many reports (mainly case reports) have been published, but so far no study has investigated
the frequency of these abnormalities in a prospective manner, have correlated the occurrence
of the different cardiac abnormalities, and have assessed which clinical variables can
predict cardiac dysfunction. And only a limited number of studies have related neurological
outcome with cardiac dysfunction.
Status | Active, not recruiting |
Enrollment | 350 |
Est. completion date | June 2008 |
Est. primary completion date | June 2008 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 10 Years and older |
Eligibility |
Inclusion Criteria: - Diagnosed with aneurysmal subarachnoid hemorrhage - Admitted within 72 hours of the bleed Exclusion Criteria: - No informed consent - Patients or patients' family unwillingness to participate |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Netherlands | Academic Medical Center | Amsterdam | NH |
Netherlands | Academic Medical Center | Amsterdam | |
Netherlands | University Medical Center Groningen | Groningen | |
Netherlands | Erasmus Medical Center Rotterdam | Rotterdam | |
Netherlands | Saint Elisabeth Hospital | Tilburg | |
Netherlands | University Medical Center Utrecht | Utrecht |
Lead Sponsor | Collaborator |
---|---|
VU University Medical Center | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Erasmus Medical Center, UMC Utrecht, University Medical Center Groningen |
Netherlands,
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