Stress Clinical Trial
— LemCogOfficial title:
A Randomised Double-blind Placebo-controlled Acute Trial of Encapsulated Lemon Balm Efficacy and Tolerance on Calmness and Mood During Periods of Cognitive Demand
NCT number | NCT06183372 |
Other study ID # | 23/25 |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | December 2, 2023 |
Est. completion date | June 30, 2024 |
This study aims to investigate the effect of a single dose (300mg) of encapsulated aqueous lemon balm extract on measures of calmness and mood during periods of cognitive demand over the course of the day in healthy adults aged 18-40 years with moderate stress (PSS entry between 14 to 26).
Status | Recruiting |
Enrollment | 130 |
Est. completion date | June 30, 2024 |
Est. primary completion date | March 30, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 40 Years |
Eligibility | Inclusion Criteria: - Healthy, between 18-40 years old - Moderate Stress problems (PSS between 14 to 26) - No alcohol or vigorous activity 24h before the task - No coffee/caffeine intake 12h before the visits - Non-smokers or Must not smoke during 7 days prior to the trial: Includes smoking tobacco, vaping nicotine, using nicotine replacement products, or occasional social smoking. - Willingness to wash out for food supplementation during 2 weeks before the experiment Exclusion Criteria: - Use medications that may affect the outcome - Any long-term psychological or physiological health conditions - Have any allergic reactions to ingredients in the capsules - Have a BMI greater than or equal to 30 - Have any allergic reactions to ingredients in the capsules - Consumed more than 400 mg of caffeine (>5 expresso) per day in the past 2 weeks - Have used any psychotropic medications, stimulants, cannabis, non-registered drug products, or illicit substances in the past 2 weeks, were at risk of drug or alcohol abuse - Taking any dietary supplements which they are unwilling to stop for the duration of the study - Have sleep disorders or are taking sleep aid medication - Fail to demonstrate adequate minimal performance on lab, computer-based cognitive tasks - Have a diagnosed neurological condition, or learning/behavioural or neurodevelopmental differences (e.g. dyslexia, autism, ADHD). |
Country | Name | City | State |
---|---|---|---|
United Kingdom | University of Reading | Reading |
Lead Sponsor | Collaborator |
---|---|
University of Reading | Naturex |
United Kingdom,
Bertuccioli A, Cardinali M, Di Pierro F, Magi S, Zonzini G. A Practical Perspective on the Use of Botanicals During the COVID-19 Pandemic: From Proven to Potential Interactions. J Med Food. 2022 Jan;25(1):1-11. doi: 10.1089/jmf.2021.0062. Epub 2021 Nov 17. — View Citation
Ghazizadeh J, Sadigh-Eteghad S, Marx W, Fakhari A, Hamedeyazdan S, Torbati M, Taheri-Tarighi S, Araj-Khodaei M, Mirghafourvand M. The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta-analysis. Phytother Res. 2021 Dec;35(12):6690-6705. doi: 10.1002/ptr.7252. Epub 2021 Aug 27. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Calmness 9-point Likert Scale | A validated 9-point Likert scale with Calmness Anchor points (CAP) ranging from 1, "Not at all Calm" to 9, "Extremely Calm" | Baseline | |
Primary | Calmness 9-point Likert Scale | A validated 9-point Likert scale with Calmness Anchor points (CAP) ranging from 1, "Not at all Calm" to 9, "Extremely Calm" | 5 hours following intervention | |
Secondary | Fatigue 9-point Likert Scale | A validated 9-point Likert scale with Fatigue Anchor points (FAP) ranging from 1, "Not at all mentally fatigued" and 9, "Extremely mentally fatigued" | Baseline | |
Secondary | Fatigue 9-point Likert Scale | A validated 9-point Likert scale with Fatigue Anchor points (FAP) ranging from 1, "Not at all mentally fatigued" and 9, "Extremely mentally fatigued" | 5 hours following intervention | |
Secondary | Subject Satisfaction 4-point Category Scale | A two-part questionnaire based on a previously published 4-category rating questionnaire. The first part asks about current levels of tiredness and mental overload, using a 4-point Likert anchored from "not at all" (score 1) to "extremely" (score 4). The second part asks how satisfied a person is with their levels of tiredness and mental overload following supplementation, and asks them to rate their overall satisfaction with the supplement, using scales "not at all satisfied" (score 1) to "entirely satisfied" (score 4). | 1 hour following intervention | |
Secondary | Subject Satisfaction 4-point Category Scale | A two-part questionnaire based on a previously published 4-category rating questionnaire. The first part asks about current levels of tiredness and mental overload, using a 4-point Likert anchored from "not at all" (score 1) to "extremely" (score 4). The second part asks how satisfied a person is with their levels of tiredness and mental overload following supplementation, and asks them to rate their overall satisfaction with the supplement, using scales "not at all satisfied" (score 1) to "entirely satisfied" (score 4). | 3 hours following intervention | |
Secondary | Subject Satisfaction 4-point Category Scale | A two-part questionnaire based on a previously published 4-category rating questionnaire. The first part asks about current levels of tiredness and mental overload, using a 4-point Likert anchored from "not at all" (score 1) to "extremely" (score 4). The second part asks how satisfied a person is with their levels of tiredness and mental overload following supplementation, and asks them to rate their overall satisfaction with the supplement, using scales "not at all satisfied" (score 1) to "entirely satisfied" (score 4). | 5 hours following intervention | |
Secondary | Visual Analogue Stress Scale | Ratings of stress are captured using 100mm Visual Analogue Scales anchored at each end by words descriptive of the minimal and maximal extremes of one statement (unipolar). On this linear scale, the person indicates how he or she is feeling at the moment by placing a mark between 2 statements concerning a specific condition of the dimension being measured. This brief instrument assesses levels of stress, anxiety, calmness and relaxation. Individual scores are combined to form 'stress/anxiety' and 'calm/relaxed' scores, where a higher score (average % along the line) represents more of the respective descriptor. | Baseline | |
Secondary | Visual Analogue Stress Scale | Ratings of stress are captured using 100mm Visual Analogue Scales anchored at each end by words descriptive of the minimal and maximal extremes of one statement (unipolar). On this linear scale, the person indicates how he or she is feeling at the moment by placing a mark between 2 statements concerning a specific condition of the dimension being measured. This brief instrument assesses levels of stress, anxiety, calmness and relaxation. Individual scores are combined to form 'stress/anxiety' and 'calm/relaxed' scores, where a higher score (average % along the line) represents more of the respective descriptor. | 1 hour following intervention | |
Secondary | Visual Analogue Stress Scale | Ratings of stress are captured using 100mm Visual Analogue Scales anchored at each end by words descriptive of the minimal and maximal extremes of one statement (unipolar). On this linear scale, the person indicates how he or she is feeling at the moment by placing a mark between 2 statements concerning a specific condition of the dimension being measured. This brief instrument assesses levels of stress, anxiety, calmness and relaxation. Individual scores are combined to form 'stress/anxiety' and 'calm/relaxed' scores, where a higher score (average % along the line) represents more of the respective descriptor. | 3 hours following intervention | |
Secondary | Visual Analogue Stress Scale | Ratings of stress are captured using 100mm Visual Analogue Scales anchored at each end by words descriptive of the minimal and maximal extremes of one statement (unipolar). On this linear scale, the person indicates how he or she is feeling at the moment by placing a mark between 2 statements concerning a specific condition of the dimension being measured. This brief instrument assesses levels of stress, anxiety, calmness and relaxation. Individual scores are combined to form 'stress/anxiety' and 'calm/relaxed' scores, where a higher score (average % along the line) represents more of the respective descriptor. | 5 hours following intervention | |
Secondary | Bond-Lader 16-item Visual Analogue Stress Scale | A widely used 16-item tool for measuring transient mood where 100mm scales anchored by various antonyms (e.g. Alert-Drowsy, Lethargic-Energetic) and are then clustered into respective mood factors alertness, calmness and contentedness | Baseline | |
Secondary | Bond-Lader 16-item Visual Analogue Stress Scale | A widely used 16-item tool for measuring transient mood where 100mm scales anchored by various antonyms (e.g. Alert-Drowsy, Lethargic-Energetic) and are then clustered into respective mood factors alertness, calmness and contentedness | 1 hour following intervention | |
Secondary | Bond-Lader 16-item Visual Analogue Stress Scale | A widely used 16-item tool for measuring transient mood where 100mm scales anchored by various antonyms (e.g. Alert-Drowsy, Lethargic-Energetic) and are then clustered into respective mood factors alertness, calmness and contentedness | 3 hours following intervention | |
Secondary | Bond-Lader 16-item Visual Analogue Stress Scale | A widely used 16-item tool for measuring transient mood where 100mm scales anchored by various antonyms (e.g. Alert-Drowsy, Lethargic-Energetic) and are then clustered into respective mood factors alertness, calmness and contentedness | 5 hours following intervention | |
Secondary | Immediate Word Recall (Rey Auditory Verbal Learning Task) | A standardised cognitive measure to episodic memory. In this task participants are visually presented with a sequential list of fifteen words where they are then given 1 minute to type as many words as they can remember. At each sitting of the task, a different word list will be presented which will be matched for linguistic familiarity, concreteness and frequency. The dependent variable is the number of words correctly recalled. | Baseline | |
Secondary | Immediate Word Recall (Rey Auditory Verbal Learning Task) | A standardised cognitive measure to episodic memory. In this task participants are visually presented with a sequential list of fifteen words where they are then given 1 minute to type as many words as they can remember. At each sitting of the task, a different word list will be presented which will be matched for linguistic familiarity, concreteness and frequency. The dependent variable is the number of words correctly recalled. | 1 hour following intervention | |
Secondary | Immediate Word Recall (Rey Auditory Verbal Learning Task) | A standardised cognitive measure to episodic memory. In this task participants are visually presented with a sequential list of fifteen words where they are then given 1 minute to type as many words as they can remember. At each sitting of the task, a different word list will be presented which will be matched for linguistic familiarity, concreteness and frequency. The dependent variable is the number of words correctly recalled. | 3 hours following intervention | |
Secondary | Immediate Word Recall (Rey Auditory Verbal Learning Task) | A standardised cognitive measure to episodic memory. In this task participants are visually presented with a sequential list of fifteen words where they are then given 1 minute to type as many words as they can remember. At each sitting of the task, a different word list will be presented which will be matched for linguistic familiarity, concreteness and frequency. The dependent variable is the number of words correctly recalled. | 5 hours following intervention | |
Secondary | Delayed Word Recall (Rey Auditory Verbal Learning Task) | A standardised cognitive measure to assess the level of delayed episodic memory. Participants will be required to type as many words as they can remember from the immediate word recall presentation after a delay of approximately 30 minutes following the initial presentation. The dependent variable is the number of words correctly recalled. | Baseline | |
Secondary | Delayed Word Recall (Rey Auditory Verbal Learning Task) | A standardised cognitive measure to assess the level of delayed episodic memory. Participants will be required to type as many words as they can remember from the immediate word recall presentation after a delay of approximately 30 minutes following the initial presentation. The dependent variable is the number of words correctly recalled. | 1 hour following intervention | |
Secondary | Delayed Word Recall (Rey Auditory Verbal Learning Task) | A standardised cognitive measure to assess the level of delayed episodic memory. Participants will be required to type as many words as they can remember from the immediate word recall presentation after a delay of approximately 30 minutes following the initial presentation. The dependent variable is the number of words correctly recalled. | 3 hours following intervention | |
Secondary | Delayed Word Recall (Rey Auditory Verbal Learning Task) | A standardised cognitive measure to assess the level of delayed episodic memory. Participants will be required to type as many words as they can remember from the immediate word recall presentation after a delay of approximately 30 minutes following the initial presentation. The dependent variable is the number of words correctly recalled. | 5 hours following intervention | |
Secondary | Modified Attention Network Task (with two blocks of Serial 3's) | A standardised measure to assess executive function and attention. In this task participants respond to the direction of a centrally presented arrow by pressing the corresponding left and right arrow keys. Across multiple trials, the target stimuli are either flanked by arrows pointing in the same direction (congruent) or opposite (incongruent). The number of flanking arrows also varies between trials (load). Two blocks are presented. In the second block, participants will be distracted by noise through headphones. In addition, during further subsections of the ANT an oral serial 3 (S3) subtractions task will also be performed to further assess attention and working memory function. In this S3 task participants subtract backwards starting with the number 50 until they can go no further. The S3 performance will be in place to add additional cognitive load and the dependent variable will be ANT performance (accuracy and reaction time) under varying conditions of congruency and load. | Baseline | |
Secondary | Modified Attention Network Task (with two blocks of Serial 3's) | A standardised measure to assess executive function and attention. In this task participants respond to the direction of a centrally presented arrow by pressing the corresponding left and right arrow keys. Across multiple trials, the target stimuli are either flanked by arrows pointing in the same direction (congruent) or opposite (incongruent). The number of flanking arrows also varies between trials (load). Two blocks are presented. In the second block, participants will be distracted by noise through headphones. In addition, during further subsections of the ANT an oral serial 3 (S3) subtractions task will also be performed to further assess attention and working memory function. In this S3 task participants subtract backwards starting with the number 50 until they can go no further. The S3 performance will be in place to add additional cognitive load and the dependent variable will be ANT performance (accuracy and reaction time) under varying conditions of congruency and load. | 1 hour following intervention | |
Secondary | Modified Attention Network Task (with two blocks of Serial 3's) | A standardised measure to assess executive function and attention. In this task participants respond to the direction of a centrally presented arrow by pressing the corresponding left and right arrow keys. Across multiple trials, the target stimuli are either flanked by arrows pointing in the same direction (congruent) or opposite (incongruent). The number of flanking arrows also varies between trials (load). Two blocks are presented. In the second block, participants will be distracted by noise through headphones. In addition, during further subsections of the ANT an oral serial 3 (S3) subtractions task will also be performed to further assess attention and working memory function. In this S3 task participants subtract backwards starting with the number 50 until they can go no further. The S3 performance will be in place to add additional cognitive load and the dependent variable will be ANT performance (accuracy and reaction time) under varying conditions of congruency and load. | 3 hours following intervention | |
Secondary | Modified Attention Network Task (with two blocks of Serial 3's) | A standardised measure to assess executive function and attention. In this task participants respond to the direction of a centrally presented arrow by pressing the corresponding left and right arrow keys. Across multiple trials, the target stimuli are either flanked by arrows pointing in the same direction (congruent) or opposite (incongruent). The number of flanking arrows also varies between trials (load). Two blocks are presented. In the second block, participants will be distracted by noise through headphones. In addition, during further subsections of the ANT an oral serial 3 (S3) subtractions task will also be performed to further assess attention and working memory function. In this S3 task participants subtract backwards starting with the number 50 until they can go no further. The S3 performance will be in place to add additional cognitive load and the dependent variable will be ANT performance (accuracy and reaction time) under varying conditions of congruency and load. | 5 hours following intervention | |
Secondary | Task Switching Test | A standardised cognitive task to assess executive function. In this task participants are presented with a computerised visual circle with 8 equally spaced radii that form 8 segments, 4 above and 4 below a bold line. A stimulus digit appears sequentially in each segment in a clockwise direction. If the digit was located above the bold line, participants then indicate whether the digit was odd or even using labelled arrow keys (left for odd, right for even). When the digit is below the bold line, participants again use the arrow keys to indicate whether the digit is higher or lower than 5 (left for higher, right for lower). The dependent variable will be TST performance (accuracy and reaction time) across all trials, and comparing switch trials (where the rule changes from the previous trial) and non-switch trials (where the rule stays the same as the previous trial). | Baseline | |
Secondary | Task Switching Test | A standardised cognitive task to assess executive function. In this task participants are presented with a computerised visual circle with 8 equally spaced radii that form 8 segments, 4 above and 4 below a bold line. A stimulus digit appears sequentially in each segment in a clockwise direction. If the digit was located above the bold line, participants then indicate whether the digit was odd or even using labelled arrow keys (left for odd, right for even). When the digit is below the bold line, participants again use the arrow keys to indicate whether the digit is higher or lower than 5 (left for higher, right for lower). The dependent variable will be TST performance (accuracy and reaction time) across all trials, and comparing switch trials (where the rule changes from the previous trial) and non-switch trials (where the rule stays the same as the previous trial). | 1 hours following intervention | |
Secondary | Task Switching Test | A standardised cognitive task to assess executive function. In this task participants are presented with a computerised visual circle with 8 equally spaced radii that form 8 segments, 4 above and 4 below a bold line. A stimulus digit appears sequentially in each segment in a clockwise direction. If the digit was located above the bold line, participants then indicate whether the digit was odd or even using labelled arrow keys (left for odd, right for even). When the digit is below the bold line, participants again use the arrow keys to indicate whether the digit is higher or lower than 5 (left for higher, right for lower).The dependent variable will be TST performance (accuracy and reaction time) across all trials, and comparing switch trials (where the rule changes from the previous trial) and non-switch trials (where the rule stays the same as the previous trial). | 3 hours following intervention | |
Secondary | Task Switching Test | A standardised cognitive task to assess executive function. In this task participants are presented with a computerised visual circle with 8 equally spaced radii that form 8 segments, 4 above and 4 below a bold line. A stimulus digit appears sequentially in each segment in a clockwise direction. If the digit was located above the bold line, participants then indicate whether the digit was odd or even using labelled arrow keys (left for odd, right for even). When the digit is below the bold line, participants again use the arrow keys to indicate whether the digit is higher or lower than 5 (left for higher, right for lower).The dependent variable will be TST performance (accuracy and reaction time) across all trials, and comparing switch trials (where the rule changes from the previous trial) and non-switch trials (where the rule stays the same as the previous trial). | 5 hours following intervention | |
Secondary | Rapid Visual Information Processing Task | A standardised cognitive task which involves presenting a series of digits on screen in quick succession. The participant will then be required to monitor the digits for sequences of three consecutive even or three consecutive odd digits. To indicate the end of a target sequence, participants will press the space bar as quickly as possible. The dependent variable is task performance (accuracy and reaction time). | Baseline | |
Secondary | Rapid Visual Information Processing Task | A standardised cognitive task which involves presenting a series of digits on screen in quick succession. The participant will then be required to monitor the digits for sequences of three consecutive even or three consecutive odd digits. To indicate the end of a target sequence, participants will press the space bar as quickly as possible. The dependent variable is task performance (accuracy and reaction time). | 1 hour following intervention | |
Secondary | Rapid Visual Information Processing Task | A standardised cognitive task which involves presenting a series of digits on a screen in quick succession. The participant will then be required to monitor the digits for sequences of three consecutive even or three consecutive odd digits. To indicate the end of a target sequence, participants will press the space bar as quickly as possible. The dependent variable is task performance (accuracy and reaction time). | 3 hours following intervention | |
Secondary | Rapid Visual Information Processing Task | A standardised cognitive task which involves presenting a series of digits on a screen in quick succession. The participant will then be required to monitor the digits for sequences of three consecutive even or three consecutive odd digits. To indicate the end of a target sequence, participants will press the space bar as quickly as possible. The dependent variable is task performance (accuracy and reaction time). | 5 hours following intervention | |
Secondary | Paced Auditory Serial Addition Task | A standardised cognitive task to assess attention and memory. The participant is presented with a string of auditory single digits and required to add each new digit to the one immediately prior to it out loud so that responses can be recorded. The dependent variable is therefore accuracy of calculation. The task comprises of 4, 2 minute blocks, where interstimulus time progressively decreases from 2.8 seconds to 1.6 seconds and cognitive demand therefore progressively increases. | Baseline | |
Secondary | Paced Auditory Serial Addition Task | A standardised cognitive task to assess attention and memory. The participant is presented with a string of auditory single digits and required to add each new digit to the one immediately prior to it out loud so that responses can be recorded. The dependent variable is therefore accuracy of calculation. The task comprises of 4, 2 minute blocks, where interstimulus time progressively decreases from 2.8 seconds to 1.6 seconds and cognitive demand therefore progressively increases. | 1 hour following intervention | |
Secondary | Paced Auditory Serial Addition Task | A standardised cognitive task to assess attention and memory. The participant is presented with a string of auditory single digits and required to add each new digit to the one immediately prior to it out loud so that responses can be recorded. The dependent variable is therefore accuracy of calculation. The task comprises of 4, 2 minute blocks, where interstimulus time progressively decreases from 2.8 seconds to 1.6 seconds and cognitive demand therefore progressively increases. | 3 hours following intervention | |
Secondary | Paced Auditory Serial Addition Task | A standardised cognitive task to assess attention and memory. The participant is presented with a string of auditory single digits and required to add each new digit to the one immediately prior to it out loud so that responses can be recorded. The dependent variable is therefore accuracy of calculation. The task comprises of 4, 2 minute blocks, where interstimulus time progressively decreases from 2.8 seconds to 1.6 seconds and cognitive demand therefore progressively increases. | 5 hours following intervention | |
Secondary | Systolic Blood Pressure | Average (triplicate) resting brachial left arm cuffed systolic blood pressure mmHg | Baseline | |
Secondary | Systolic Blood Pressure | Average (triplicate) resting brachial left arm cuffed systolic blood pressure mmHg | 1 hour following intervention | |
Secondary | Systolic Blood Pressure | Average (triplicate) resting brachial (left arm) cuffed systolic blood pressure mmHg | 3 hour following intervention | |
Secondary | Systolic Blood Pressure | Average (triplicate) resting brachial (left arm) cuffed systolic blood pressure mmHg | 5 hour following intervention | |
Secondary | Diastolic Blood Pressure | Average (triplicate) resting brachial (left arm) cuffed diastolic blood pressure mmHg | Baseline | |
Secondary | Diastolic Blood Pressure | Average (triplicate) resting brachial (left arm) cuffed diastolic blood pressure mmHg | 1 hour following intervention | |
Secondary | Diastolic Blood Pressure | Average (triplicate) resting brachial (left arm) cuffed diastolic blood pressure mmHg | 3 hours following intervention | |
Secondary | Diastolic Blood Pressure | Average (triplicate) resting brachial (left arm) cuffed diastolic blood pressure mmHg | 5 hours following intervention | |
Secondary | Heart Rate | Average (triplicate) resting brachial (left arm) cuffed heart rate bpm | Baseline | |
Secondary | Heart Rate | Average (triplicate) resting brachial (left arm) cuffed heart rate bpm | 1 hour following intervention | |
Secondary | Heart Rate | Average (triplicate) resting brachial (left arm) cuffed heart rate bpm | 3 hours following intervention | |
Secondary | Heart Rate | Average (triplicate) resting brachial (left arm) cuffed heart rate bpm | 5 hours following intervention |
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