Stress Clinical Trial
Official title:
Impact of Premedication With Midazolam in Aspiration Procedures On Stress Levels During IVF Procedures
The aim of the study is to determine whether premedication with midazolam before oocyte aspiration in IVF procedures affects the amount of (oxidative) stress in women undergoing IVF and whether stress is also transmitted to the follicular fluid of aspirated follicles. The primary endpoint is the impact of stress during aspiration on the success of medically assisted fertilization (IVF / ICSI in the stimulated cycle).
The procedure of in vitro fertilisation (IVF) is used to treat the infertility problems. The
procedure includes ovary aspiration, to isolate oocytes. During the aspiration the patient is
sedated with short-term intravenous aesthetic. Premedication is often used in
anaesthesiology, and includes drugs application 30 minutes prior to procedure to sedate and
treat the anxieties of the patient. One of the most often used drugs in premedication is
midazolam. As the procedure is quite stressful for the patients, our aim is to investigate
the influence of midazolam premedication on the stress release during the oocyte aspiration
procedure, as well as its influence on the whole IVF procedure. Therefore, patients will be
divided into two groups, control and midazolam. Blood samples will be taken before and during
the procedure. Stress, antioxidant parameters (with glutathione and catalase) and oxidative
status will be monitored in serum and follicular fluid.
The results will be correlated with subjective stress levels in the two groups in an effort
to establish ties with IVF results.
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