Stress Disorders, Post-Traumatic Clinical Trial
Official title:
Potentiation of Trauma Exposure in Post-traumatic Stress Disorder by Repeated Transcranial Magnetic Stimulation : A Control Randomized Study
The aim of this study is to assess the efficacy in PTSD treatment of concomitant voluntary reactivation of personal traumatic memories with neuromodulation of the right dorsolateral prefrontal cortex using 10Hz rTMS, compared to 1Hz rTMS, during 2 weeks.
Post-Traumatic Stress Disorder (PTSD) is characterized by intrusive and persistent memory of
past result from an event causing or able to cause death, be a threat of death, a severe
injury or constitute a threat for physical integrity. It is a frequent disorder in general
population (8%). In France, The most frequent traumatic events causing PTSD are serious
accidents, rape, physical assaults, violence, etc. PTSD treatment involves antidepressant and
cognitive and behavioural psychotherapy, which encourage exposure to elements that remind the
trauma (memories, circumstances), with the objective of reducing the fear associated with the
traumatic memories. Innovative therapeutic strategies aim to improve the psychotherapeutic
effect with enhancement drugs or using neuromodulatory techniques, such as repeated
transcranial magnetic stimulation (rTMS).
The aim of this study is to assess the efficacy in PTSD treatment of concomitant voluntary
reactivation of personal traumatic memories with neuromodulation of the right dorsolateral
prefrontal cortex using 10Hz rTMS, compared to 1Hz rTMS, during 2 weeks.
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