Stress Disorders, Post-Traumatic Clinical Trial
— SEMEOfficial title:
Stress and Emotional Memory : Functional Neuroanatomy of Post-traumatic Stress Disorder in Adolescents
A broad group of disorders is associated with severe stress existence in children or
adolescents. The most characteristic result, and one of the most serious being the state of
post-traumatic stress disorder (PTSD), whose main source consists of physical or sexual
violence, and to a lesser extent, accidents public road or natural disaster, whose child was
the subject or witness. PTSD is associated with a deleterious effect on cognition and
including the mnemonic operation. The painful reminder of the traumatic event is one of the
most disabling symptoms. However, there are many other memory disorders that experimental
studies gradually update. They maintain a close link with emotional regulation that
disturbed you know if PTSD. However the majority of studies on emotion and cognition and
their relationship with brain activity took adult subject. Work in adolescents are few on
the morphological study, on rare neurobehavioral and reduced to two studies of functional
neuroimaging. Contrary to what is observed in adults, morphological studies report
consistently, no reduction in hippocampal volume. There is no study in the idle state. Two
studies in functional MRI, the first highlighted in PTSD patients inhibition of the activity
of the anterior cingulate cortex (ACC) to stimuli such as to evoke the trauma, a second
reported increased activity in the prefrontal cortex Median (mPFC) in a inhibition. The
objective task of our study is to evaluate the impact of psychological trauma on brain
structures involved in the emotional component of the memory (amygdala, hippocampus,
prefrontal cortex in particular). For this, the investigators will take in 33 adolescents,
including patients with posttraumatic symptomatology and matched controls free of trauma
age, several neuroimaging exams, anatomical and functional. The functional review will
include some rest and another in activation during episodic memory task designed to assess
the influence of self-perception on memory impairment observed in patients. The
investigators will check, for each group of patients and controls, the involvement of
cortical structures in relation to the regulation of emotional memory (CCA, amygdala and
hippocampus). The anatomy of the hippocampus benefit specific imaging methods developed in
the unit INSERM U923. Endocrine correlates of stress tests will be studied by a
fully-traumatic by salivary cortisol sampling.
This research will clarify the mechanisms involved in emotional and memory impairments
secondary to psychological trauma, their relationship with self (judgment and self-esteem)
and studying their morphological substrates. A longer-term goal is to offer help in the
diagnosis and monitoring of young patients with posttraumatic symptomatology.
Status | Completed |
Enrollment | 19 |
Est. completion date | April 2015 |
Est. primary completion date | April 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 13 Years to 18 Years |
Eligibility |
Inclusion Criteria: - Subjects aged 13-18 years - Informed consent signed by the legal representative and adolescents (e) itself. - Speaking French as their mother tongue - patients:subjects with a history of psychological trauma (eg, accidents of public roads (without head trauma), physical or sexual violence) recruited in the care services of hospitals, the diagnosis of chronic PTSD is made using a standardized interview (SCID). - Healthy controls : subjects who do not have a history of psychological trauma, nor PTSD Exclusion Criteria: - ASD, schizophrenia, ADHD - Head injury with loss of consciousness - Regular or recent use of alcohol or drugs - chronic neurological or endocrine disorder - use of medication that could interfere with the mnemonic or metabolic measurements (psychotropic, hypnotics, anxiolytics, neuroleptics, benzodiazepines, drugs, antiepileptics anti-inflammatory, anti-histamines, central analgesics and muscle relaxants) - Contraindications to MRI (claustrophobia, metallic object intracorporal) - Manual Predominance left - Severe mental retardation evaluated using two subtests from the WISC-IV scales and WAIS III - Reading Disorders valued using the read speed test |
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Country | Name | City | State |
---|---|---|---|
France | Service de Pédopsychiatrie | Caen |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Caen |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Amplitude of the BOLD fMRI signal measured at rest and during cognitive tasks (activation) | baseline | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05620381 -
Health and Sleep Assessment After the Strasbourg Attacks of December 11, 2018
|
||
Completed |
NCT02856412 -
Improving Mind/Body Health and Functioning With Integrative Exercise
|
N/A | |
Recruiting |
NCT05400200 -
PTSD and Self-regulation: Coping, Emotional Regulation and Cognitive Control and Their Relationships to Symptom Management
|
N/A | |
Not yet recruiting |
NCT06088303 -
Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication
|
N/A | |
Not yet recruiting |
NCT03652922 -
Propranolol Reactivation Mismatch (PRM) Treatment for PTSD
|
Phase 4 | |
Completed |
NCT02875912 -
Prospective Evaluation of Family Care Rituals in the ICU
|
N/A | |
Completed |
NCT01589575 -
Anxiety and Depression in Relatives of Critically Ill Patients: Spouses Versus Other Close Relatives
|
N/A | |
Completed |
NCT01291368 -
Sedation Influence on Delirium and Post-traumatic Stress-disorder as a Result of Hospitalization in Intensive Care
|
N/A | |
Completed |
NCT00990106 -
Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD)
|
N/A | |
Active, not recruiting |
NCT00657787 -
Development of a Post-Traumatic Stress Disorder (PTSD) Population Registry for Veterans
|
||
Completed |
NCT00880152 -
Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder: A Pilot Study
|
N/A | |
Completed |
NCT01365247 -
Concurrent Treatment for Substance Dependent Individuals With Post-Traumatic Stress Disorder (PTSD)
|
N/A | |
Completed |
NCT00835627 -
Treatment Trial for Psychogenic Nonepileptic Seizures
|
Phase 4 | |
Completed |
NCT00514956 -
Effect of Emotional Freedom Technique and Diaphragmatic Breathing on Post Traumatic Stress Disorder (PTSD)
|
Phase 1 | |
Completed |
NCT00419029 -
Motivational Interviewing to Engage Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) Veterans in Mental Health Treatment
|
N/A | |
Completed |
NCT00333710 -
Evaluating a Telehealth Treatment for Veterans With Hepatitis C and PTSD
|
N/A | |
Completed |
NCT01120847 -
Post Traumatic Stress Disorder (PTSD), Sleep Disordered Breathing And Genetics: Effects On Cognition
|
||
Completed |
NCT00069225 -
Brain Structure and Function Before and After Treatment for Post-Traumatic Stress Disorder
|
N/A | |
Completed |
NCT00055354 -
Acupuncture for the Treatment of Post-Traumatic Stress Disorder (PTSD)
|
N/A | |
Completed |
NCT00186212 -
Alternative Support for Rural and Isolated Women in an HMO
|
Phase 3 |