Clinical Trials Logo

Clinical Trial Summary

The objective of this study is to determine the effect of Bemiparin, a low molecular weight heparin, on implantation rate in women with unexplained recurrent implantation failure undergoing IVF/ICSI treatment.


Clinical Trial Description

Recurrent implantation failure (RIF), defined as failure of conception following three or more consecutive In Vitro Fertilization (IVF) cycles despite the transfer of good quality embryos, is a major cause of distress amongst infertile couples. While factors underlying implantation failure are many, most cases remain unexplained. In order to improve pregnancy outcomes and delivery rates in women with unexplained RIF, various investigational treatments have been proposed. The investigators propose a prospective controlled randomized comparative study to evaluate the effect of Bemiparin on implantation rates in women with unexplained RIF. A total of 200 patients will be recruited and randomized between two groups. The study group will receive Bemiparin plus standard care; while the control group will receive only standard care. Treatment will start on the day following embryo transfer and will be continued until 12 weeks gestation in the event of pregnancy. The primary objective is to determine the effect of Bemiparin on implantation rate in women with unexplained recurrent implantation failure. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02607319
Study type Interventional
Source American University of Beirut Medical Center
Contact
Status Completed
Phase Phase 4
Start date November 2015
Completion date July 2022

See also
  Status Clinical Trial Phase
Completed NCT01955356 - Embryo Implantation After Induced Endometrial Injury N/A
Completed NCT01330784 - Assessment of the Therapeutic Utility of hMG-HP N/A
Completed NCT01330771 - Assessment of the Therapeutic Utility of r-FSH in Association With hMG-HP N/A
Active, not recruiting NCT05079685 - HyFoSy Versus HSG as a Diagnostic Technique for Tubal Patency.
Completed NCT04605003 - Effectiveness of Nasal Endoscope Sterilization Using a Novel Rig-S™ Device N/A
Completed NCT01331720 - Assessment of the Effectiveness and Tolerability of Ovarian Hyperstimulation N/A
Completed NCT01331733 - Comparative Assessment of the Clinical Utility of Ovarian Stimulation With Menotropin Versus Menotropin Plus GnRH Antagonist N/A
Not yet recruiting NCT02648555 - A Lifestyle Intervention to Improve in Vitro Fertilization Results N/A
Suspended NCT00749853 - Efficacy of Ovarian Stimulation Based on FSHR Genotype Status Phase 3
Recruiting NCT03177122 - Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology Phase 4
Completed NCT03169166 - The Use of GnRH Agonist Trigger for Final Follicle Maturation in Women Undergoing Assisted Reproductive Technologies Phase 4
Completed NCT01406964 - Chlamidia Antibodies Test for Tubal Factor Screening N/A
Completed NCT01430650 - Endometrial Priming for Embryo Transfer Phase 4
Completed NCT03173404 - Benefits of Hysteroscopy Prior to Performing a Cycle of in Vitro Fertilization/Intracytoplasmic Sperm Injection N/A
Completed NCT03561129 - Embryotransfer Operator and Pregnancy Rate
Recruiting NCT05173597 - Real-world Evidence on Follitropin Delta Individual Dosing
Recruiting NCT04026282 - To Investigate the Cumulative Live Birth Rates Using GnRH Antagonist or Agonist Protocol for COS in ART Treatment N/A
Completed NCT03619707 - Oral Versus Vaginal Progesterone in the Luteal Support in Cryo-warmed Embryo Transfer Cycles Phase 4