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NCT01955356 Clinical Trial

Embryo Implantation After Induced Endometrial Injury

Sterility Clinical Trial

Official title:
Evaluation of Induced Endometrial Injury in the Subsequent IVF Cycle.

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01955356
Other study ID # 1306-C-119-CV/IVI Valencia
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date October 2013
Est. completion date November 21, 2022

Study information
Verified date January 2023
Source Instituto Valenciano de Infertilidad, IVI VALENCIA
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Some studies have revealed that an induced endometrial injury could improve embryo human implantation in patients with implantation failure. The purpose of this study is to determine whether the induced endometrial injury could be beneficial for regular patients undergoing IVF

Description:

Endometrial induced injury has been suggested that could improve embryo implantation in cases of patients with recurrent implantation failure. The mechanisms that induce that improvement remain unknown. We want to analyse if the endometrial induce injury could be useful in cases of standard patients who require assisted reproductive techniques. For that purpose we will start a randomized controlled trial with the ideal background in implantation in ART, the egg donation programme.

Recruitment information / eligibility
Status Completed
Enrollment 600
Est. completion date November 21, 2022
Est. primary completion date November 21, 2022
Accepts healthy volunteers No
Gender Female
Age group 19 Years to 44 Years
Eligibility Inclusion Criteria: - 19-44 aged women - 19-29.9 Kg/m2. - 1st or 2nd fresh embryo transfer ( egg donation). - 1 or 2 blastocysts available. - written agreement. - > or = 6 mms endometrial thickness. Exclusion Criteria: - Premature ovarian failure. - Endometrial pathology. - Insufficient endometrial development. - Hydrosalpinx - Mullerian malformations.

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Scratching
Endometrial biopsy

Locations
Country Name City State
Spain IVI Valencia Valencia

Sponsors (8)
Lead Sponsor Collaborator
Instituto Valenciano de Infertilidad, IVI VALENCIA Instituto Valenciano de Infertilidad, IVI Alicante, IVI Barcelona, IVI Bilbao, IVI Madrid, IVI Murcia, IVI Sevilla, IVI Vigo

Country where clinical trial is conducted

Spain, 

Outcome
Type Measure Description Time frame Safety issue
Primary Ongoing implantation rate (OIR) 12 weeks of pregnancy
Secondary Live born rate (LBR) 9 months after embryo transfer
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