Clinical Trials Logo

Clinical Trial Summary

The aim of this study is to assess the impact of different protocols used for ovarian stimulation during in vitro fertilization procedures (IVF) on prothrombotic biomarkers (blood coagulation markers associated with thromboembolic events) in the units of reproductive medicine in two university hospitals (HUG, Geneva and CHUV, Lausanne).


Clinical Trial Description

HEMO-STIM is a prospective multicentric cohort study of subfertile women undergoing ART. It is an epidemiologic observational study. All women older than 18 years attending the reproductive medicine unit (UMREG, Geneva, HUG or UMR, Lausanne, CHUV) and undergoing an IVF have been and will be recruited consecutively and included. The type of stimulation protocol used is recorded. All measurements (specific haemostasis test with a thrombin generation assay before and after adjunction of APC) that are part of the study will be performed in the HUG laboratories in order to limit inter-dosage variability. The 1st blood test will be performed at inclusion in the absence of any hormonal treatment (T1). A 2nd blood test will be performed on the day of ovulation triggering (T2). A 3rd blood test will be performed 7 days after ovulation triggering (T3). The comparison of different protocols has never been performed and data on the effect of antagonist protocols for IVF on haemostasis are lacking. The measurement of intermediate biomarkers of thromboembolic risk during different IVF stimulation protocols (agonists and antagonists) would allow the comparison of their thrombotic profile and to optimize the risk/benefit ratio during ART by prescribing protocols at lower vascular risk, in particular in women identified as being at risk for thromboembolic events. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04188444
Study type Observational
Source University Hospital, Geneva
Contact
Status Completed
Phase
Start date March 1, 2017
Completion date September 30, 2020

See also
  Status Clinical Trial Phase
Completed NCT03438682 - Real World Effectiveness and Safety of Hysteroscopic (Essure®) Compared to Laparoscopic Sterilization
Completed NCT02522806 - Endometrial Local Injury Before First IVF : Evaluation of Pregnancy Rate N/A
Recruiting NCT05518175 - Patient-centered Outcomes After Permanent Female Sterilization Procedure(POPS Trial) N/A
Recruiting NCT04314869 - Uterus Transplantation Procedure From a Live Donor N/A
Recruiting NCT05279560 - Ovarian PRP (Platelet Rich Plasma) Injection for Follicular Activation N/A
Completed NCT03788421 - Comparison Between 2 Techniques for Bilateral Salpingectomy N/A
Completed NCT04809428 - vNOTES in Elective Bilateral Salpingectomy for Sterilization
Recruiting NCT06434233 - Opioid Use After Laparoscopic Salpingectomy N/A