Relationship Between Level of GPCR Autoantibodies and Cardiac Structure & Funtions Based on UCG and CMR

STEMI Clinical Trial

Official title:

Relationship Between Level of GPCR Autoantibodies and Cardiac Structure & Funtions Based on UCG and CMR

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT05368584
• Other study ID #: BFH-autoantibodies and STEMI
• Status: Active, not recruiting
• Start date: May 7, 2022
• Est. completion date: December 2022

Study information

• Verified date: May 2022
• Source: Beijing Friendship Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study is a prospective cohort study，we want to observe the changes of different cardiovascular antibody levels in STEMI patients undergoing emergency PCI;and combined with different cardiovascular antibody levels and various indicators, evaluate the impact of ischemia-reperfusion injury and prognosis in STEMI patients after emergency PCI.

Description:

This study mainly observed the changes of different cardiovascular antibody levels in STEMI patients undergoing emergency PCI by measuring autoantibodies; and the changes of autoantibodies in STEMI patients compared with coronary angiography-negative patients. At the same time, combined with different cardiovascular antibody levels and various indicators, the effect of ischemia-reperfusion injury and prognosis after emergency PCI in STEMI patients was evaluated. The correlation between autoantibody changes and imaging indicators in STEMI patients was evaluated by cardiac color Doppler ultrasound and CMR.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 1
• Est. completion date: December 2022
• Est. primary completion date: December 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• STEMI patients meet the diagnostic criteria of "Guidelines for the Diagnosis and Treatment of Acute ST-segment Elevation Myocardial Infarction (2015)"; ?STMEI patients undergoing emergency PCI should undergo emergency PCI within 12 hours of onset at Beijing Friendship Hospital affiliated to Capital Medical University; ? The selected patients were able to complete the MRI and STE examinations; ? They agreed to be enrolled in the trial and signed the informed consent.

Exclusion Criteria:

• Past myocardial infarction or revascularization (PCI or CABG); ?Congestive heart failure LVEF<40%; ?Atrial fibrillation; ?Renal insufficiency (GFR<30 ml/min); disease; ? rheumatic immune system disease; ? malignant tumor; ? claustrophobia; ? contraindication to CMR;

Related Conditions & MeSH terms

• STEMI

Locations

Country	Name	City	State
China	Beijing Friendship Hospital	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Beijing Friendship Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	ß1-AA, ß2-AA, a1-AA, M2-AA and AT1-AA OD values	About 10ml of venous blood was collected on the second day of admission, serum was separated, and the OD values of ß1-AA, ß2-AA, a1-AA, M2-AA and AT1-AA were detected by ELISA.	Admission Baseline