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Clinical Trial Summary

This study will evaluate the safety of PD-1 knockout EBV-CTL cells in treating EBV (Epstein-Barr virus) positive advanced stage malignancies. Blood samples will also be collected for research purposes.


Clinical Trial Description

This is a study of CRISPR-Cas9 mediated PD-1 knockout-T cells from autologous origin. Patients are assigned to receive 4 circles of cell therapy. The safety and clinical response are evaluated. Biomarkers and immunological markers are also monitored. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03044743
Study type Interventional
Source The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Contact Baorui Liu, MD
Phone 0086-25-83106666-61331
Email baoruiliu07@163.com
Status Recruiting
Phase Phase 1/Phase 2
Start date April 7, 2017
Completion date March 2022

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