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Clinical Trial Summary

This phase II trial tests whether sacituzumab govitecan given before radical cystectomy works in treating patients with non-urothelial bladder cancer. Sacituzumab govitecan contains a monoclonal antibody, called sacituzumab, linked to a chemotherapy drug, called govitecan. Sacituzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of cancer cells, known as TROP2 receptors, and delivers govitecan to kill them. Giving sacituzumab govitecan before radical cystectomy may make the surgery more effective in patients with muscle invasive bladder cancer.


Clinical Trial Description

OUTLINE: Patients receive sacituzumab govitecan intravenously (IV) over 3 hours on days 1 and 8 of each cycle. Treatment repeats every 21 days for 3 cycles in the absence of disease progression or unacceptable toxicity. Within 2-6 weeks after last dose, patients undergo radical cystectomy and pelvic lymph node dissection. After completion of study treatment, patients are followed up at 1-3 months after radical cystectomy and then every 3-6 months for 2 years. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05581589
Study type Interventional
Source University of Washington
Contact Patrick Panlasigui
Phone 206-606-7486
Email ppanlas2@fredhutch.org
Status Recruiting
Phase Phase 2
Start date June 15, 2023
Completion date April 30, 2026

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