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Clinical Trial Summary

This research study is designed to look at the effects of the combination of vorinostat (Suberoylanilide Hydroxamic Acid or Zolinza) and tamoxifen on breast cancer tissue. The investigators will do this by comparing tissues from the original breast biopsy to tissues obtained after taking vorinostat and tamoxifen for 2 weeks.


Clinical Trial Description

Key eligibility criteria include:

- Newly diagnosed invasive breast cancer awaiting surgery or neoadjuvant (preoperative) treatment

- No use of hormone contraceptives or replacement therapy within 30 days prior to the diagnostic breast cancer biopsy (unless willing to have an additional biopsy prior to starting the study)

- No prior or current use of any therapy to treat the current breast cancer. ;


Study Design

Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science


Related Conditions & MeSH terms


NCT number NCT01194427
Study type Interventional
Source Sidney Kimmel Comprehensive Cancer Center
Contact
Status Terminated
Phase Phase 2
Start date March 2011
Completion date November 2011

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