Circulating Tumor Cells in Operative Blood in Patients With Bladder Cancer

Stage II Bladder Urothelial Carcinoma Clinical Trial

Official title: The Impact Radical Cystectomy Has on the Expulsion of Circulating Tumor Cells

Status Withdrawn

Clinical Trial Summary

This pilot clinical trial studies the impact of radical cystectomy (surgery) on the expulsion (release) of circulating tumor cells into the blood stream in patients with bladder cancer. Significant surgery such as radical cystectomy may cause the expulsion of tumor cells. Studying the release of tumor cells into the circulation may help doctors understand the impact that radical cystectomy has on tumor metastasis and/or tumor recurrence.

Clinical Trial Description

PRIMARY OBJECTIVES:

I. To detect the numbers of circulating tumor cells (CTCs) during and following radical cystectomy in both the peripheral and central line.

SECONDARY OBJECTIVES:

I. To ensure the safety and of using the femoral vein to access the central venous blood supply for patients with primary bladder cancer and the withdrawal of blood from both a peripheral and central line.

OUTLINE:

Patients undergo placement of a central line via the right femoral vein and undergo open radical cystectomy (ORC). Blood samples are collected and analyzed for CTCs pre-surgery, at 30 minutes and 1 hour once ORC begins, post-surgery, and 7 days after surgery.

After completion of study, patients are followed up at 2 weeks and at 1 month. ;

Related Conditions & MeSH terms

• Carcinoma, Transitional Cell
• Neoplastic Cells, Circulating
• Stage II Bladder Urothelial Carcinoma

• NCT number: NCT02514408
• Study type: Observational
• Source: University of Southern California
• Status: Withdrawn
• Phase: N/A
• Start date: February 5, 2018
• Completion date: March 5, 2019