Stage 5 Chronic Kidney Disease Clinical Trial
Official title:
Frailty, Cardiovascular Function and Risk of Falling in Patients Receiving Haemodialysis Treatment
The purpose of this study is to explore the relative importance of the frailty and cardiovascular function as potential exercise-modifiable risk factors for falling in patients receiving haemodialysis.
Falls and fall-related injuries in elderly people are common worldwide, and ageing
populations will further raise the burden and costs. Within the UK, falls have become a major
government target, as they have been responsible for increased injuries and hospital
admissions in elderly people.
The fall rate amongst patients on haemodialysis (HD) is much greater than in the general
population. There are many well established risk factors for falling, many of which are
commonly present in patients on HD, including severe loss of muscle mass, high levels of
inactivity, co-existing medical conditions and a high number of medications.
Nonetheless, the main cause of health complications and death in Chronic Kidney Disease (CKD)
is due to cardiovascular disease. Cardiovascular disease may result in suboptimal regulation
of blood pressure and heart rate during exercise, dialysis therapy, body transfers, and
general activities of daily living. Associated symptoms such as dizziness, generalised
fatigue, and muscular weakness, are commonly reported and may further predispose patients on
HD to balance deficits and falls.
Despite the evidence of high falls rates in patients on HD and the growing number of elderly
patients, falls and their associated risk factors have received little research attention.
The aim of this study therefore is explore the relative importance of selected
exercise-modifiable risk factors for falling amongst patients on HD.
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