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Clinical Trial Summary

A window of opportunity study which would allow brief treatment of HPV negative SCCHN with a CDK4/6 inhibitor, in the pre-operative setting, with biomarker analyses of pre and post treatment tissue. Given that the standard treatment for this population is surgical resection, this would not impact or alter standard therapy for this population. The goal will be to learn more about the alterations in pRB1 levels, as well as other signaling markers, in order to be able to eventually plan a biomarker driven treatment study.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03179956
Study type Interventional
Source Fox Chase Cancer Center
Contact
Status Terminated
Phase Early Phase 1
Start date April 2, 2018
Completion date January 10, 2019

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