Clinical Trials Logo

Clinical Trial Summary

The study is aimed at assessing the influence of two betaine doses (2.5 g∙d-1 and 5 g∙d-1) supplemented for three weeks in a group of speed-strength trained athletes on anaerobic capacity in Wingate test, performance in CrossFit-like exercise test - Fight Gone Bad, alterations in body compositions and total body water.


Clinical Trial Description

The main aim of the project is the assessment of the effects of 3 weeks supplementation with two doses of betaine (2.5 g∙d-1 and 5 g∙d-1) on anaerobic capacity, CrossFit performance, body composition, and betaine metabolism in a group of male speed-strength trained athletes.

The study is designed as a double-blind, randomized, placebo-controlled crossover trial. 80 male participants will be divided randomly into two parallel groups: one receiving 2.5 g·d-1 betaine and the second receiving 5 g·d-1 betaine. In both experimental groups participants will receive both betaine supplement or placebo in a random order. The supplementation periods (betaine and placebo) will last for three weeks each and will be separated by a 3-week washout. The participants will attend four study meetings at the Institute of Human Nutrition and Dietetics, Poznan University of Life Sciences, Poland. Food intake before and during the intervention will be assessed with the use of food diary and intakes of macro- and micronutrients will be calculated with the use of Dieta 5.0 software. On each visit Wingate ergocycling test will be performed, body composition will be measured and blood samples will be taken. The same day in the afternoon/evening hours the Fight Gone Bad (FGB) test will be performed. Body composition will be assessed based on air displacement plethysmography technology using the Bod Pod®. Moreover, total body water content will be analyzed by bioelectric impedance with the use of a BIA 101S analyzer. Anaerobic capacity will be assessed using the classical Wingate test on a cycloergometer. In order to assess CrossFit performance the FGB test will be performed. In blood samples the investigators plan to analyze concentrations of: lipoproteins and triglycerides (biochemical analyzer), betaine (LC-MS method), amino acid profile (LC-MS method), and testosterone (ELISA). MTHFR genotype will be analyzed with using a PCR-RFLP method. Data will be analyzed using the STATISTICA 12 software program. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03702205
Study type Interventional
Source Poznan University of Life Sciences
Contact Emilia E Zawieja, MSc
Phone +48 61 846 60 57
Email emilia.zawieja@up.poznan.pl
Status Recruiting
Phase Phase 2/Phase 3
Start date October 15, 2018
Completion date October 12, 2021

See also
  Status Clinical Trial Phase
Completed NCT05597189 - Clinical Study for Palliative/Preventive Treatment of Chronic Back Pain N/A
Recruiting NCT05444959 - The Impact of Exercise / Stress Stimuli on HMB Supplementation Efficacy Phase 2/Phase 3
Completed NCT03165357 - Sodium Bicarbonate Supplementation in Athletes Phase 3
Completed NCT03406065 - Sodium Bicarbonate Supplementation in Combat Sports Athletes Phase 2/Phase 3
Recruiting NCT04549610 - HMB and Exercise-induced Muscle Damage Phase 2/Phase 3
Completed NCT03822663 - The Influence of Caffeine Supplementation on Specific Performance and Training Activities Phase 3
Completed NCT06390670 - The Effect of Colostrum Bovinum Supplementation in Endurance Athletes Phase 2/Phase 3
Recruiting NCT05516212 - Caffeine Kinetics and CrossFit®-Specific Performance Phase 2/Phase 3
Completed NCT01235325 - The Effect of Vitamin K Supplementation on Bone Health in Adult Crohn's Disease Patients Phase 4
Completed NCT03028649 - The Effect of β-hydroxy-β-methylbutyrate Supplementation on Physical Capacity and Body Composition in Trained Athletes Phase 3
Completed NCT04427319 - The Efficacy β-Alanine Supplementation in Performance Outcomes of Road Professional Endurance Cyclists N/A
Completed NCT05750342 - Clinical Trial to Analyze the Efficacy of a Supplement Extracted From Persimmon on Overweight / Obesity. N/A
Active, not recruiting NCT03810404 - Acute Sodium Bicarbonate Supplementation in Athletes Phase 3
Completed NCT01275885 - Vitamin D Intervention in Infants - Pilot Phase 4
Completed NCT05525871 - Effects of Nitrates and Citrulline Malate on Performance in Professional Professional Soccer N/A
Recruiting NCT05878106 - Creatine Supplementation and Resistance Training in Patients With Breast Cancer N/A
Not yet recruiting NCT06327646 - Maternal Adherence to MMS in Nepal N/A