Spondylodiscitis Clinical Trial
Official title:
Preliminary Study. The Value of 18F-FDG PET/CT Compared to MRI in Diagnosing Residual Disease in Patients With Spondylodiscitis
MRI has shoved little correlation with the clinical finding during treatment of
spondylodiscitis (infection in the vertebrae and/or discs). Since PET/CT is almost as good
as MRI in diagnosing spondylodiscitis the hypothesis and this study is that PET/CT is better
in predicting residual disease in patients with spondylodiscitis.
Preliminary study.
In the last years there has been reported increasing incidence of spondylodiscitis. The
increase is mainly thought to be caused by the increasing elderly population and the
increasing amount of spinal instrumentation in this population. The symptoms range from
backache to severe neurological deficits. Up to 1/3 of cases are reported to be culture
negative and cases can therefore be difficult to diagnose.
MRI is thought to be the main imaging technique to visualise infection. But with the
increasing availability of 18-F FDG PET/CT, it is reported to be nearly as efficient to
diagnose spinal infection.
During the long antibiotic treatment of spondylodiscitis, the clinicians have no real good
imaging technique to predict residual disease since MRI during the remodelling fase of the
spine will mimic no difference or worsening.
Since 18-F-FDG PET marks areas with a high amount of inflammatory cells it may also be
faster in returning to normal images and therefore correlates better to actual status than
MRI.
Some of the purposes of this study are therefore:
- To describe changes on PET/CT and MRI at index and after 4, 8 12 and 26 weeks and
compare these to the clinical findings as well as inflammatory biomarkers.
- To investigate the correlation between normalisation of inflammatory biomarkers and
changes on MRI and PET/CT.
;
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05806905 -
Spondylodiscitis Cases at Assiut University Hospital
|
||
| Recruiting |
NCT05610098 -
Gene Expression Profiles in Spinal Tuberculosis.
|
||
| Completed |
NCT02554227 -
Cytokine Profiles and suPAR in Spondylodiscitis
|
||
| Not yet recruiting |
NCT04436328 -
Conservative Versus Surgical Treatment of Native Vertebral Osteomyelitis
|
N/A | |
| Not yet recruiting |
NCT04749082 -
Follow up Patients With Thoracolumbar Spondylodiscitis Surgically Treated by Posterior Approach
|
||
| Completed |
NCT05486494 -
Spine Registry University Hospital of Cologne- Department of Orthopedics
|
||
| Completed |
NCT04655950 -
Immobilization and Neurological Complications in Patients With Vertebral Osteomyelitis.
|
||
| Active, not recruiting |
NCT03524209 -
CORset Versus OstéoSynthese in Adult Pyogenic Spondylodiscitis
|
N/A |