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Seronegative Oligoarthritis of the Knee Study (SOKS) — SOKS  

Spondylarthropathies Clinical Trial

Official title:
Intra-articular and Intravenous Infliximab in the Treatment of Resistant Seronegative Oligoarthritis of the Knee

Clinical Trial Summary

The aim of this study is to establish the efficacy and duration of effect of intra-articular (IA) infliximab vs intravenous infliximab vs current standard care (IA steroid injections) in seronegative oligoarthritis. All patients will have seronegative arthritis affecting less than 5 joints but including at least one knee. 10 patients will receive IA infliximab injections to the affected knee, 10 will receive IA steroid injections to the affected knee and 10 will receive a course of intravenous infliximab. Patients will not be aware of their group as this is a placebo-controlled study.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01216631
Study type Interventional
Source University of Leeds
Contact Philip G Conaghan, FRCP
Phone +44 1133924884
Email p.conaghan@leeds.ac.uk
Status Recruiting
Phase Phase 2
Start date September 2010
Completion date September 2012
View Details
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